血清半乳糖凝集素3和可溶性ST2预测心肺复苏后急性心力衰竭患者近期预后的价值

Value of sST2 and Galectin-3 in predicting the recent clinical prognosis of patients with acute heart failure after CPR

目的:探讨血清可溶性ST2(soluble ST2,sST2)、半乳糖凝集素3(Galectin-3)对心脏骤停心肺复苏(cardiopulmonary resuscitation,CPR)成功后发生急性心力衰竭的患者近期预后的评估价值。方法:ELISA法检测160例CPR后发生急性心力衰竭的患者CPR后24h的血清sST2、半乳糖凝集素3水平,依据随访出院后6个月的终点事件(出院后6个月内患者因出现急性心力衰竭再次入院或死亡)分为发生事件组(A组,58例)和未发生事件组(B组,102例),同时检测患者左室舒张末期内径(LVEDD)、左室射血分数(LVEF)。采用ROC曲线分析其评估急性心力衰竭患者近期预后的价值。结果:A组血清sST2、半乳糖凝集素3水平均高于B组(均P<0.01)。两者联合分析能提高对患者短期预后的预测价值(P<0.01)。LVEDD与LVEF随着sST2和半乳糖凝集素3水平的变化而变化。sST2高表达组(>200ng/L)、半乳糖凝集素3高表达组(>20ng/ml)患者病死率均高于sST2、半乳糖凝集素3低表达组(均P<0.05)。结论:血清sST2、半乳糖凝集素3联合分析能提高对CPR后发生急性心力衰竭患者近期预后的预测价值。

Objective：To explore the value of soluble ST2（sST2）and Galectin-3 in predicting the recent clinical prognosis of patients with acute heart failure（AFH）after cardiopulmonary resuscitation（CPR）.Method：The level of Serum sST2 and Galectin-3 of 160 patients with AFH after CPR were detected by ELISA.According to the end events（readmission or death due to AFH or acute exacerbation of chronic heart failure）during follow-up for 6 months,the 160 patients were divided into two groups of A（with end events,58 cases）and B（without end events,102 cases）.We detected LVEDD,LVEF of the 160 patients at the same time.The values of soluble sST2 and Galectin-3 in peridicting the recent clinical prognosis of the patients in 6 months were analyzed by receiver-operating characteristic（ROC）curve.Result：Serum levels of sST2 and Galectin-3 in group A were higher than those in group B（P0.01）.Combined analysis of sST2 and Galectin-3 can improve the value of recent clinical prognosis of patients with AFH after CPR.Conclusion：Joint detection of Serum sST2 and Galectin-3 can well predict the recent clinical prognosis of patients with AFH after CPR.