盐酸氨溴索注射液联合沙丁胺醇对慢性支气管炎急性发作老年患者症状改善及肺通气功能的影响

Effect of Ambroxol Hydrochloride Injection combined with Salbutamol on symptoms improvements and pulmonary ventilation function in elderly patients with acute exacerbation of chronic bronchitis

目的探究盐酸氨溴索注射液联合沙丁胺醇对慢性支气管炎急性发作老年患者症状改善及肺通气功能的影响。方法 84例老年慢性支气管炎急性发作患者,采用随机数字表法分为对照组和观察组,各42例。对照组予以盐酸氨溴索注射液治疗,观察组在对照组基础上予以沙丁胺醇治疗。比较两组症状改善情况及治疗前后肺通气功能指标[呼气高峰流量(PEFR)、第1秒用力呼气容积(FEV1)]。结果观察组咳嗽消失时间、喘息消失时间、啰音消失时间分别为(4.28±2.06)、(3.67±1.38)、(3.92±1.17)d,均短于对照组的(6.95±1.84)、(6.76±1.64)、(5.56±1.95)d,差异有统计学意义(P<0.05)。治疗前两组PEFR、FEV1比较,差异无统计学意义(P>0.05);治疗后观察组PEFR、FEV1高于对照组,差异有统计学意义(P<0.05)。结论盐酸氨溴索注射液联合沙丁胺醇治疗老年慢性支气管炎急性发作患者,疗效显著,可增强患者肺通气功能,改善患者临床症状,值得推广。

Objective To investigate the effect of Ambroxol Hydrochloride Injection combined with Salbutamol on symptom improvements and pulmonary ventilation function in elderly patients with acute exacerbation of chronic bronchitis. Methods A total of 84 elderly patients with acute exacerbation of chronic bronchitis were divided into control group and observation group according to the random number table method, 42 cases in each group. The control group was treated with Ambroxol Hydrochloride Injection, and the observation group was treated with Salbutamol on the basis of the control group. The improvements of symptoms, pulmonary ventilation function indexes [peak expiratory flow rate（PEFR）, forced expiratory volume in first second（FEV1）] before and after treatment between the two groups were compared. Results The disappearance time of cough, wheezing and rale in the observation group were（4.28±2.06）d,（3.67±1.38）d and（3.92±1.17）d respectively, which were significantly shorter than（6.95±1.84）d,（6.76±1.64）d and（5.56±1.95）d in the control group, the differences were statistically significant（P〈0.05）. There was no significant difference in PEFR and FEV1 between the two groups before treatment（P〈0.05）, and the PEFR and FEV1 of the observation group after treatment were significantly higher than those of the control group, the differences were statistically significant（P〈0.05）. Conclusion The efficacy of Ambroxol Hydrochloride Injection combined with Salbutamol in the treatment of elderly patients with acute exacerbation of chronic bronchitis is significant. It can enhance the pulmonary ventilation function and improve the clinical symptoms, is worth popularizing.