缬沙坦联合氨氯地平在治疗老年高血压中的可行性分析

Feasibility analysis of Valsartan combined with Amlodipine in the treatment of senile hypertension

目的分析缬沙坦联合氨氯地平治疗老年高血压的可行性。方法 150例老年高血压患者,按照随机数字表法分为A组(利用缬沙坦治疗)、B组(利用氨氯地平治疗)、C组(利用缬沙坦联合氨氯地平治疗),各50例。观察比较三组患者治疗效果、治疗前后24 h血压的变化及不良反应发生情况。结果 C组总有效率为98%,明显高于A组的88%、B组的86%,差异有统计学意义(P<0.05),A组与B组总有效率比较差异无统计学意义(P>0.05)。治疗前三组24 h收缩压和舒张压比较差异无统计学意义(P>0.05);A组、B组、C组在治疗1年后24 h收缩压和舒张压均较治疗前显著下降(P<0.05),且C组患者的24 h收缩压和舒张压明显低于A组和B组,差异有统计学意义(P<0.05)。三组患者在治疗期间均无明显的不良反应发生。结论缬沙坦联合氨氯地平可有效降低和控制老年患者高血压,值得临床上推广应用。

Objective To analyze the feasibility of Valsartan combined with Amlodipine in the treatment of senile hypertension. Methods A total of 150 patients with senile hypertension were divided into group A（treated with Valsartan）, group B（treated with Amlodipine） and group C（given Valsartan combined with Amlodipine） according to the random number table method, 50 cases in each group. The therapeutic effect, the average blood pressure of 24 h before and after treatment and the incidence of adverse reactions were compared in the three groups. Results The total effective rate of group C was 98%, which was significantly higher than 88% of group A and 86% of group B, the differences were statistically significant（P〈0.05）. There was no significant difference in the total effective rate between group A and group B（P〈0.05）. There were no significant differences in 24 h systolic blood pressure and diastolic blood pressure in the three groups before treatment（P〈0.05）. In group A, group B and group C, the 24 h systolic blood pressure and diastolic blood pressure after 1 year of treatment were significantly lower than those before treatment（P〈0.05）. The 24 h systolic blood pressure and diastolic blood pressure of group C after treatment were significantly lower than those of group A and group B, the differences were statistically significant（P〈0.05）. No obvious adverse reactions occurred in the three groups during treatment. Conclusion The treatment of Valsartan combined with Amlodipine can effectively reduce and control hypertension in elderly patients, and is worthy of clinical promotion and application.