高血压合并2型糖尿病患者血压、血脂、血糖和Hcy水平及临床意义

Levels of blood pressure,blood glucose and serum homocysteine among patients of hypertension with type 2 diabetes and their clinical significance

目的探讨高血压合并2型糖尿病(T2DM)患者血压、血脂、血糖及血清同型半胱氨酸水平(Hcy)的临床意义。方法选择2014年6月-2016年12月的原发性高血压患者150例,按是否合并T2DM分为高血压合并T2DM组(115例)和单纯高血压组(35例),高血压合并T2DM组再根据血压分级分为1级高血压组(37例)、2级高血压组(43例)及3级高血压组(35例)。比较各组间空腹血糖(FBG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)及Hcy等差异。结果高血压合并T2DM组FBG、TG、TC、LDL-C及Hcy均显著高于单纯高血压组(P<0.05)。三组间FBG、TG、TC以及Hcy水平随着高血压分级水平降低而依次降低,差异有统计学意义(P<0.05)。高血压合并T2DM患者血压分级与FBG、TG、TC及Hcy均呈正相关(P<0.05)。结论高血压并发T2DM可促进糖代谢异常、血脂紊乱及高Hcy的进展,随着血压的升高,其严重程度逐渐增加,因此,对高血压患者应早期重视T2DM的防治。

Objective To investigate the levels and clinical significance of blood pressure,blood glucose and serum homocysteine（ Hcy） among the patients of hypertension with type 2 diabetes（ T2 DM）. Methods According to whether the merger of T2 DM,150 cases of hypertensive patients were divided into hypertension with T2 DM group（ 115 cases） and simple hypertension group（ 35 cases） from June 2014 to December 2016. Based on the classification of blood pressure of hypertension with T2 DM,the patients were divided into grade 1 hypertension group high density lipoprotein cholesterol（ 37 cases）,grade 2 hypertension group（ 43 cases） and grade 3 hypertension（ 35 cases）. Serum levels of fasting blood glucose（ FBG）,triglyceride（ TG）,total cholesterol（ TC）,low density lipoprotein cholestern（ LDL-C）,HDL-C and Hcy among the patients were compared. Results The levels of FBG,TG,TC,LDL-C and Hcy in hypertension with T2 DM group were significantly higher than those of the simple hypertension group（ P〈0. 05）. The levels of FBG,TG,TC and Hcy of three groups were decreased with reducing the grading of hypertension with statistical differences（ P〈0. 05）. Grading of blood pressure in hypertension with T2 DM patients was significantly positive correlation with the levels of FBG,TG,TC and Hcy（ P〈0. 05）. Conclusion Hypertension associated with T2 DM promotes the progress of glucose metabolism disorder,dyslipidemia and high Hcy,with the increase of blood pressure,the degree of severity increased. So,more attention should be paid for early prevention and treatment for hypertension T2 DM.