热休克蛋白90α在非小细胞肺癌患者血浆中的表达及临床意义

Expression and clinical significance of heat shock protein 90 alpha in plasma of patients with non-small cell lung cancer

目的分析热休克蛋白90α在非小细胞肺癌患者血浆中的表达及其临床意义。方法回顾性分析2015年1月—2017年8月期间在滁州市第一人民医院诊断的87例非小细胞肺癌患者和46例健康体检者的HSP90α、CEA、CYFRA21-1和SCC检测结果,对检测结果进行统计分析。结果非小细胞肺癌组HSP90α、CEA、CYFRA21-1和SCC结果与对照组比较均显著升高,差异有统计学意义(P均<0.05);HSP90αROC曲线下面积是0.858,最佳诊断截点值为90.95 ng/ml、灵敏度65.7%、特异度92.3%。HSP90α与CEA、CYFRA21-1及SCC经Kappa分析一致性不满意,Kappa值分别是0.318、0.201、0.248。结论 HSP90α在非小细胞肺癌患者血浆中高水平表达,对非小细胞肺癌具有较高的诊断价值。

Objective To analyze the expression and clinical significance of heat shock protein 90 alpha in plasma of patients with non-small cell lung cancer.Methods 87 cases of patients suffered non-small cell lung cancer diagnosed in the First People＇s Hospital of Chuzhou during January 2015 and August 2017and 46 cases of health volunteers were enrolled in this study. And we analyzed the results of HSP90 alpha, CEA, CYFRA21-1 and SCC in serum retrospectively.Results The concentration of HsPg0, CEA, CYFRA21-1 and SCC in non- small cell lung cancer group were significantly higher than those of the control group, the differences were statistically significant （P〈0.05）. The AUC of the roc curve of HSP90 alpha was 0.858, the best diagnostic cut- off value was 90.95 ng/mL, the sensitivity was 65.7% and the specificity was 92.3%. The consistency between HSP90 and CEA, CYFRA21-1 and SCC were not satisfied according to Kappa analysis. The Kappa values were 0.318, 0.201 and 0.248, respectively.Conclusions HSP90 alpha is highly expressed in the plasma of patients with non-small cell lung cancer, and has a high diagnostic value for non-small cell lung cancer.