尼卡地平与乌拉地尔在脑出血急性期血压管理中的有效性与安全性

The efficacy and safety of nicardipine and urapidil in the management of blood pressure during acute cerebral hemorrhage

目的尼卡地平与乌拉地尔在脑出血急性期血压管理中的有效性及安全性探讨。方法研究中将本院2016年1月—2017年12月收治的脑出血急性期患者50例纳为研究对象,将其根据入院单双顺序均分组为:对照组25例(给药乌拉地尔)、观察组25例(给药尼卡地平);将两组患者各项临床数据详细整理后作对比分析。结果观察组患者血压达标率(150.64±9.21/98.01±0.47)mm Hg及其恢复目标血压时间(35.19±28.30)min、血压变异系数(11.20±2.35)等情况均优于对照组,P<0.05;两组患者不良反应发生率分别为12.0%、28.0%比较不存在差异,P>0.05。结论脑出血急性期患者接受尼卡地平行血压管理的效果显著,临床实际应用时根据患者的病情给药,以保证患者用药安全。

Objective To explore the efficacy and safety of nicardipine and urapidil in the management of blood pressure in the acute phase of eerebral hemorrhage.Methods In the study, 50 cases of patients suffered acute cerebral hemorrhage treated in our hospital during January 2016 and December 2017 were included. They were grouped according to the odd-even of the order of hospital admission： 25 patients in the control group were treated with urapidil and 25 cases in observation group were given nicardipine. The clinical data of the two groups were carefully sorted and compared.Results The up to standard rate of blood pressure （ 150.64±9.21/98.01±0. 47） mmHg, the time recovered to target blood pressure （35.19±28.30） min, and variation coefficient of blood pressure （11.20±2.35） in the observation group were preceded the control group （P〈0.05）. The incidence of adverse reactions in the two groups were 12.0% and 28.0%, respectively, there was no statistically significant difference between the two groups （P 〉 0. 05 ）. Conclusions In the acute phase of cerebral hemorrhage, nicardipine performs significant effect in blood pressure management. In order to ensure the safety of drug use, the drug should be given according to the patient＇s condition in clinical practice.