火针赞刺法对急性期带状疱疹疼痛和血清中P物质的影响

Shallow Fire-needle Acupuncture Stimulation Plus Cupping Relieves Neuralgia and Down-regulates Serum Substance P Level in Patients with Acute Herpes Zoster

目的:观察火针赞刺法对急性期带状疱疹(AHZ)局部神经痛和血清中P物质(SP)的影响。方法:将60例AHZ患者随机分为对照组和治疗组,每组30例。对照组予口服泛昔洛韦片(0.25g/次,3次/d)、甲钴胺片(0.5g/次,3次/d),治疗组在对照组基础上加用火针赞刺阿是穴治疗(1次/d),均治疗7d。比较两组治疗前后的疼痛视觉模拟量尺(VAS)评分,ELISA法检测血清SP含量。分析治疗组VAS评分和SP的相关性。结果:治疗后两组VAS评分和血清中的SP含量均较治疗前显著下降(P<0.01);治疗组较对照组下降更明显(P<0.01)。治疗组VAS评分下降值和SP下降值呈高度正相关(P<0.01)。结论:在常规西药基础上加用火针赞刺法可调节血清中SP浓度,从而加快AHZ局部神经疼痛的缓解。

Objective To observe the influence of repeated shallow fire-needle acupuncture stimulation plus cupping on local neuralgia and serum substance P（SP）content in patients with acute herpes zoster（AHZ）.Methods A total of 60 cases of AHZ patients were randomly divided into control（medication）group and treatment（medication plus fire-needle）group（n=30 in each）.Patients of both groups were ordered to take Famciclovir（0.25 g/time,three times a day）and Mecobalamin（0.5 g/time,three times a day）orally for 7 days.In addition,patients of the treatment group were also treated by repeated shallow fire-needle stimulation and cupping,once a day for 7 days.Before and after the treatment,the patient＇s pain severity was assessed using visual analogue scale（VAS）and serum SP concentration was measured using ELISA.Results After the treatment,the VAS scores and serum SP concentrations in both groups were significantly decreased in comparison with those of their own pre-treatment（P〈0.01）,and were significantly lower in the treatment group than in the control group（P〈0.01）.There was a highly positive correlation between the decreased VAS score and serum SP content in the treatment group（P〈0.01）.Conclusion Repeated shallow fire-needle stimulation plus cupping can accelerate the relief of local neuralgia in AHZ patients,which may be associated with its effect in down-regulating serum SP level.