高压氧综合治疗突发性耳聋的临床观察

Clinical observation on the effects of comprehensive hyperbaric oxygen therapy in the treatment of sudden deafness

目的观察高压氧综合治疗突发性耳聋的临床疗效。方法选取2015年7月至2017年7月于杭州市红十字会医院耳鼻咽喉科住院治疗的患者98例（100耳），将所有患者按随机数字表法分为高压氧组、对照组，每组50耳，每组再根据听力损失累及的频率和程度分为低频下降型、高频下降型及平坦下降与全聋型3个小组。对照组予鼠神经生长因子、银杏叶提取物、灯盏花素针及激素药物治疗，高压氧组在对照组基础上予高压氧治疗。2组治疗3个疗程后，分别比较2组患者的临床疗效、受损频率听力提高幅度。结果高压氧组治疗总有效率（94%）明显高于对照组（78%），差异有统计学意义（P〈0.05）。高压氧组的治愈率（34%）明显高于对照组（16%），差异有统计学意义（P〈0.05）。平坦下降与全聋型患者高压氧组总有效率（96%）明显高于对照组（73%），差异有统计学意义（P〈0.05）。结论高压氧联合药物综合治疗较单纯药物治疗突发性耳聋疗效明显，值得临床推广。

To observe the clinical effects of comprehensive hyperbaric oxygen （HBO） therapy in the treatment of sudden deafness.MethodsNinety-eight patients （100 ears） hospitalized in the Department of Otorhinolaryngology, Hangzhou Red Cross Hospital from July 2015 to July 2017 were enrolled as research objects. All the patients were randomly divided into the HBO group and the control group, each consisting of 50 ears. Then, the groups were further divided into 3 subgroups： the low frequency descent group, the high frequency descent/flat descent group and the full deafness group, by depending on the frequency and intensity of hearing loss. The control group was treated with nerve growth factor （NGF）, Ginkgo biloba extract, Breviscapine needle and hormone, while the experiment group was supplemented with HBO in addition to the treatment received by the control group. After 3 courses of treatment, clinical effects and amplitude improvement in the impaired hearing frequency were compared between the 2 groups.ResultsTotal effective rate of the experiment group was 94%, which was significantly higher than that of the control group （78%）, with statistical significance（P〈0.05）. Cure rate of the experimental group was 34%, which was higher than that of the control group （16%）, also with statistical significance（P〈0.05）. Total effective rate of the experimental group with flat descent and full deafness was 96%, which was also superior to that of the control group （73%）, and statistical significance could be seen when comparisons were made between the groups（P〈0.05）.ConclusionsHBO combined with NGF and other drugs could produce better efficacy, as compared with simple drug therapy. For this reason, it was worth further clinical extension.