原发性高血压患者血清FKN水平与血管内皮功能的关系

The relationship between serum FKN level and vascular endothelial function in patients with essential hypertension

目的探讨原发性高血压(EH)患者血清不规则趋化因子Fractalkine(FKN)水平的变化及其对血管内皮功能的影响。方法选取2016年7月~2017年7月就诊于海南省三亚市人民医院门诊的EH患者106例作为观察组,选取同期体检健康者80名作为对照组。比较观察组入院时与对照组血清FKN、超敏C反应蛋白(hs-CRP)、内皮素(ET-1)、一氧化氮(NO)、二甲基精氨酸(ADMA)水平及肱动脉内皮依赖性血管舒张功能(FMD);比较观察组患者治疗前后血压变化;比较观察组治疗前后血清FKN、hs-CRP、ET-1、NO、ADMA水平及FMD;分析EH患者血清FKN与hs-CRP、ET-1、NO、ADMA水平及FMD的相关性。结果观察组患者入院时血清FKN、hs-CRP、ET-1、ADMA水平显著高于对照组(P<0.05);观察组血清NO、FMD水平低于对照组(P<0.05)。治疗后观察组患者收缩压、舒张压均显著降低,与治疗前比较差异有统计学意义(P<0.05)。观察组治疗后血清FKN、hs-CRP、ET-1、ADMA水平较治疗前显著降低,NO、FMD水平较治疗前显著升高(P<0.05)。Pearson相关分析显示,EH患者血清FKN与hs-CRP、ET-1、ADMA水平呈正相关(r=0.332、0.456、0.432,均P<0.05),与NO、FMD呈负相关(r=-0.443、-0.505,均P<0.05)。结论 EH患者血清FKN水平异常升高,并影响血管的内皮功能,FKN水平升高可能与血压升高介导血管损伤有关。

Objective To explore the changes of serum fractalkine（FKN） level in patients with essential hypertension（EH） and its effect on vascular endothelial function. Methods One hundred and six EH patients in Sanya People＇s Hospital from July 2016 to July 2017 were selected as the observation group, 80 cases of healthy check-up were selected as the control group. The levels of serum FKN and high sensitive C reactive protein（hs-CRP）, endothelin（ET-1） and nitric oxide（NO）, two methyl arginine（ADMA） and brachial artery endothelial dependent vasodilation（FMD） of observation group at admission and control group were compared; the changes of blood pressure of observation group before and after treatment were observed; the serum levels of FKN, hs-CRP, ET-1, NO, ADMA and FMD in the observation group before and after treatment were compared; the correlation between serum FKN and hs-CRP, ET-1, NO, ADMA and FMD in EH patients was analyzed. Results At admission, the levels of serum FKN, hs-CRP, ET-1 and ADMA in the observation group were significantly higher than those in the control group（P〈0.05）, while the levels of serum NO and FMD in the observation group were lower than those in the control group（P〈0.05）. After treatment, the systolic and diastolic pressures of the observation group were significantly lower than those before treatment, there was a statistically significant difference（P〈0.05）. The levels of serum FKN, hs-CRP, ET-1 and ADMA in the observation group were significantly lower than those before treatment, and the levels of NO and FMD were significantly higher than those before treatment（P〈0.05）. Pearson correlation analysis showed that serum FKN level was positively correlated with hs-CRP, ET-1 and ADMA level in EH patients（r = 0.332, 0.456, 0.432, all P〈0.05）, and negatively correlated with NO and FMD（r =-0.443,-0.505, all P〈0.05）. Conclusion The serum level of FKN in EH patients is abnormal elevate and affects the endothelial function of blood vessels. Elevated FKN level may be associated with increased blood pressure mediated vascular injury.