软组织肉瘤组织中软组织肉瘤组织中JMJD3的表达及其临床意义

Expression of JMJD3 in soft tissue sarcoma and its clinical significance

【目的】探讨组蛋白去甲基化酶JMJD3表达与软组织肉瘤(soft tissue sarcoma,STS)临床病理特征的关系,以及JMJD3表达对软组织肉瘤患者总体生存期的影响。【方法】通过免疫组织化学染色方法检测64例软组织肉瘤肿瘤组织中JMJD3的表达情况,分析其与软组织肉瘤临床病理特征相关性以及其对软组织肉瘤患者总体生存期的影响。【结果】JMJD3高表达与肿瘤患者的年龄(P=0.039)、肿瘤大小(P=0.032)、组织分级(P<0.001)、临床分期(P<0.001)、侵袭深度(P=0.001)以及肿瘤是否发生转移(P=0.017)显著相关,但与患者的性别(P=0.147)及肿瘤部位(P=0.636)无关。JMJD3高表达组肿瘤患者的总体生存期较低表达组明显降低(P<0.001)。【结论】JMJD3高表达与软组织肉瘤术后的肿瘤进展有关,它有望成为预测软组织肉瘤预后不良的分子标志物。

【Objective】To explore the correlation between the expression of histone demethylases JMJD3 and clinicopathological characteristics of soft tissue sarcoma（STS）, and identify the clinical significance of JMJD3 expression on the overall survival of soft tissue sarcoma.【Methods】Immunohistochemistry（IHC） staining was performed on 64 paraffin-embedded tumor tissues of soft tissue sarcoma to explore the expression of JMJD3. The correlation between JMJD3 expression and clinicopathological characteristics as well as the impact of JMJD3 expression on overall survival of soft tissue sarcoma were analyzed.【Results】High levels of JMJD3 protein expression were found to be significantly correlated with age（P=0.039）, tumor size（P=0.032）, malignancy grade（P〈0.001）, TNM stage（P〈0.001）, invasion depth（P=0.001） and metastasis（P=0.017）, but showed no relationship with gender（P=0.147） and tumor location（P=0.636）. High expression of JMJD3 was tightly correlated with a shorter overall survival（P〈0.001）.【Conclusion】High expression of JMJD3 may play a pivotal role in the progression of soft tissue sarcoma after surgery. It is expected to be a molecular marker for predicting poor prognosis of soft tissue sarcoma.