拉莫三嗪治疗脑血管病后继发癫痫的临床疗效

Clinical effect of lamotrigine in the treatment of secondary epilepsy after cerebrovascular disease

目的观察和分析拉莫三嗪治疗脑血管病后继发癫痫的临床疗效。方法选取2016年1月至2017年12月我院收治的脑血管病后继发癫痫患者96例,随机分为对照组(48例,采用卡马西平治疗)和观察组(48例,采用拉莫三嗪治疗)。观察两组患者的临床疗效、癫痫发作情况以及不良反应发生情况。结果观察组治疗总有效率为93.75%,高于对照组的72.92%(P<0.05)。观察组患者的癫痫发作次数、癫痫发作持续时间均显著优于对照组(P<0.05)。观察组患者的不良反应总发生率低于对照组(P<0.05)。结论采用拉莫三嗪治疗脑血管病后继发癫痫能够显著改善患者的临床治疗效果,减少癫痫发作的次数,缩短癫痫发作持续时间,降低不良反应发生率。

Objective To observe and analyze the clinical efficacy of lamotrigine in the treatment of secondary epilepsyafter cerebrovascular disease. Methods A total of 96 patients with secondary epilepsy after cerebrovascular disease admittedin our hospital from January 2016 to December 2017 were randomly divided into control group （48 cases, treated withcarbamazepine） and observation group （48 cases, treated with lamotrigine）. The clinical efficacy, epilepsy status and adversereactions of the two groups were observed. Results The total effective rate of treatment in the observation group was 93.75%,which was higher than 72.92% in the control group（P〈0.05）. The frequency and duration time of epilepsy in the observationgroup were significantly better than those in the control group （P〈0.05）. The total incidence of adverse reactions in theobservation group was lower than that in the control group （P〈0.05）. Conclusion Lamotrigine in the treatment of secondaryepilepsy after cerebrovascular disease can significantly improve the clinical treatment of patients, reduce the frequency ofepilepsy, shorten the duration time of epilepsy and reduce the adverse reactions.