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地氯雷他定联合加巴喷丁治疗老年性瘙痒症的疗效分析

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摘要 目的观察地氯雷他定联合加巴喷丁治疗老年性瘙痒症的临床效果。方法选取100例老年性瘙痒症患者,分为观察组和对照组。观察组给予地氯雷他定联合加巴喷丁治疗,对照组单独给予地氯雷他定治疗,采用视觉模拟量表(VAS)评定瘙痒评分,比较两组治疗2周后的治疗效果。结果观察组治愈率54.0%,总有效率88.0%;对照组治愈率20.0%,总有效率52.0%;两组总有效率和治愈率差异均有统计学意义(均P<0.05)。治疗2周后,观察组瘙痒缓解44例(88.0%),对照组瘙痒缓解26例(52.0%),两组瘙痒缓解率差异有统计学意义(P<0.05);两组治疗后瘙痒程度评分差异有统计学意义(P<0.05)。结论地氯雷他定联合加巴喷治疗老年性瘙痒症可有效控制瘙痒症状,提高患者生活质量,值得临床推广应用。
出处 《现代实用医学》 2018年第8期1096-1097,共2页 Modern Practical Medicine
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  • 1陈新谦 金有预.新编药物学:第16版[M].北京:人民卫生出版社,1997.299.
  • 2Morris GL. Gabapentin [ J ]. Epilepsia, 1999,40 ( 5 ) :63 - 70.
  • 3Rose MA,Kam PCA. Gabapentin:pharmacology and its use in pain management [ J ]. Anaesthesia,2002,57:451 - 462.
  • 4Armijo JA, Pena MA, Adin J, et al. A sociation between patient age and gabapentin serum concentration-to-dose ratio:a preliminary mult- ivariate analysis [J]. Ther Drug Monit.2004.26(6) :633 -637.
  • 5Parsons B, Tive L, Huang S. Gabapentin : a pooled analysis of adverse events from three clinical trials in patients with postherpetic neuralgia [ J]. Am J Geriatr Pharma- cotber,2004,2 (3) : 157 - 162.
  • 6Uchitel OD, Di Guilmi MN, Urbano FJ, et al. Acute modulation of calcium currents and synaptic transmission by gabapentinoids [ J ]. Channels,2010,4(6) :490 -496.
  • 7Hendrich J,Van Minh AT, Heblich F,et al. Pharmacological disrup- tion of calcium channel trafficking by the alpha2delta ligand gabapen- tin [ J ]. Proc Natl Acad Sci USA,2008,105 (9) :3628 - 3633.
  • 8Hara K, Sata T. Inhibitory effect of gabapentin on N-methyl-D-aspar- tate receptors expressed in Xenopus oocytes [ J]. Acta Anaesthesiol Scand ,2007,51 ( 1 ) :122 - 128.
  • 9Tran-Van-Minh A, Dolphin AC. The atpha2delta ligand gabapentin inhibits the Rabl 1-dependent recycling of the calcium channel sub- unit alpha2delta-2 [ J]. Neurosci,2010,30 : 12856 - 12867.
  • 10Gazulla J, Tintore MA. The P/Q-type vol:tage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit [ J ]. Med Hypotheses,2007,68( 1 ) : 131 - 136.

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