白鹤藤中的1个新生物碱

A new alkaloid from Argyreia acuta

目的研究白鹤藤Argyreia aceta的化学成分。方法采用硅胶、大孔吸附树脂、MCI GEL CHP 20P反相树脂、Sephadex LH-20、制备液相色谱等方法对其化学成分进行分离,并根据理化性质及波谱数据鉴定化合物结构。结果从白鹤藤中分离鉴定10个化合物,分别为咖啡酸乙酯(1)、粗毛豚草素(2)、槲皮素(3)、东莨菪苷(4)、N-反式-对香豆酰基酪胺(5)、甘露醇(6)、橙皮苷(7)、华佗豆丙碱-4′-O-β-D-(6-O-反式香豆酰基)-葡萄糖苷(8)、假荆芥属苷(9)、高车前苷(10)。结论化合物8为新化合物,命名为白鹤藤碱。化合物2、3、6、7、9、10为首次从白鹤藤中分离得到。

Objective To study chemical constituents of Argyreia acuta. Methods The chemical constituents were isolated and purified by silica gel, macroporous resin adsorption, MCI GEL CHP 20 P, Sephadex LH-20 chromatography, and preparative liquid chromatography. Their structures were identified by physicochemical properties and spectral analysis. Results Ten compounds were isolated and identified as ethyl caffeate（1）, hispidulin（2）, quercetin（3）, scopolin（4）, paprazine（5）, mannitol（6）, hesperetin（7）, ipalbidinium-4′-O-β-D-（6-O-trans-coumaroyl）-glucoside（8）, nepitrin（9）, and homoplantaginin（10）. Conclusion Compound 8 is a new compound named argyreiacutine, and compounds 2, 3, 6, 7, 9, and 10 are isolated from A. acuta for the first time.