摘要
I型干扰素(IFN-I)是一种多效细胞因子家族,具有广泛的生物学效应,现主要应用于抗病毒治疗。然而有研究表明,I型干扰素也可通过调控炎症因子的分泌以及免疫细胞的分化成熟,从而抑制肠道内的炎症反应。本文针对IFN-I在肠道炎症中的抗炎作用进行综述,揭示了IFN-I在肠道内稳态维持过程中的扮演的重要角色。
Type Ⅰ interferon（IFN-I） is a multipotent cytokine family with extensive biological effects and is now mainly used for antiviral therapy. However, studies have shown that type I interferon can also inhibit the inflammatory response in the gut by regulating the secretion of inflammatory factors and the differentiation of immune cells. This paper is to review the anti-inflammatory effects of IFN-I in intestinal inflammation and the important role of IFN-I in the homeostasis of the intestinal tract.
作者
李思澄
胡琼源
吴秀文
LI Si-cheng;HU Qiong-yuan;WU Xiu-wen(Nanjing Medical University,Nanjing 211166,Jiangsu,China;Medical School of Nanjing University,Nanjing 210093,Jiangsu,China;Department of Surgery,Jinling Hospital,Nanjing 210002,Jiangsu,China)
出处
《肠外与肠内营养》
北大核心
2018年第4期248-251,共4页
Parenteral & Enteral Nutrition
基金
国家自然科学基金(81571881)
江苏省重点研发项目(BE2016752)
江苏省研究生科研与实践创新计划项目(SJCX18_0439)
关键词
一型干扰素
肠黏膜
抗炎反应
TypeⅠ interferon
Intestinal mucosa
Anti-inflammatory response
