溶瘤病毒治疗与肿瘤微环境及机体免疫的关系

Relationship between oncolytic viral therapy and tumor microenviroument or body immunity

溶瘤病毒（OV）与肿瘤微环境及机体免疫系统间的关系对于抗肿瘤治疗效果至关重要。OV的抗瘤机制比较复杂，涉及了直接的细胞毒作用、肿瘤微环境免疫原性的改变、肿瘤血管的影响及诱导体内系统性的抗肿瘤免疫反应，继而杀伤已感染及未感染的肿瘤细胞，达到持续全身性的治疗效果。

The interaction between oncolytic virus （OV） and the tumor microenvironment or body immune system is critical to the outcome of antitumor therapy. The antitumor mechanism of OV is complex, which involves direct cytotoxic effects, immunogenicity change in tumor microenvironment, the role of tumor vasculature, and activating of the antitumor immunity response, to reach the goal of killing the tumor cells infected or uninfected, and confirming the continous favorable effects.