以埃索美拉唑、奥美拉唑为主的三联疗法治疗幽门螺杆菌相关性胃溃疡的疗效比较

Comparison of Efficacy Between Three-drug Therapies of Esomeprazole and Omeprazole in Treatment of Helicobacter Pylori Associated Gastric Ulcer

目的:比较以埃索美拉唑、奥美拉唑为主的三联疗法治疗幽门螺杆菌(helicobacterpylori,Hp)相关性胃溃疡的疗效。方法:选取2014年6月至2017年6月天津海滨人民医院收治的Hp相关性胃溃疡患者86例,以随机数字表法分为Ⅰ组、Ⅱ组,每组43例。Ⅰ组患者给予以埃索美拉唑为主的三联疗法,Ⅱ组患者给予以奥美拉唑为主的三联疗法。比较两组患者的Hp根除率和治疗前后白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平的差异。结果:Ⅰ组患者的总有效率为93.02%(40/43),明显高于Ⅱ组的79.07%(34/43),差异有统计学意义(P<0.05)。Ⅰ组患者的Hp根除率为95.35%(41/43),明显高于Ⅱ组患者的81.40%(35/43),差异有统计学意义(P<0.05)。治疗后,Ⅰ组患者的IL-8、TNF-α水平明显低于Ⅱ组,差异均有统计学意义(P<0.05)。结论:与以奥美拉唑为主的三联疗法相比,以埃索美拉唑为主的三联疗法治疗Hp相关性胃溃疡的疗效更显著。

OBJECTIVE： To compare the efficacy between three-drug therapies of esomeprazole and omeprazole in treatment of helicobacter pylori（ Hp） associated gastric ulcer. METHODS： 86 patients with Hp associated gastric ulcer admitted into Haibin People＇s Hospital from Jun. 2014 to Jun. 2017 were selected and divided into group Ⅰ and group Ⅱvia random number table,with 43 cases in each. Group Ⅰ was given three-drug therapy of esomeprazole,and groupⅡwas given three-drug therapy of omeprazole. Differences in Hp eradication rates,interleukin-8（ IL-8） and tumor necrosis factor-α（ TNF-α） levels between two groups before and after treatment were compared. RESULTS： The total effective rate of group Ⅰ was 93. 02%（ 40/43）,which was significantly higher than that of group Ⅱ（ 79. 07%,34/43）,with statistically significant difference（ P〈0. 05）. The Hp eradication rates of group I was 95. 35%（ 41/43）,which was significantly higher than that of group Ⅱ（ 81. 40%,35/43）,with statistically significant difference（ P〈0. 05）. After treatment,the IL-8 and TNF-α levels of group Ⅰ were significantly lower than those of group Ⅱ,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： Compared with the three-drug therapy of omeprazole,the efficacy of three-drug therapies of esomeprazole in treatment of Hp associated gastric ulcer is more remarkable.