赖氨肌醇维生素B_(12)和葡萄糖酸钙锌口服液联合治疗手足口病后脱甲的疗效观察

Observation on Efficacy of Lysine Inositol Vitamin B_(12) Combined with Calcium and Zinc Gluconates Oral Liquid in Treatment of Defluvium Unguium of Hand-foot-mouth Disease

目的:探讨赖氨肌醇维生素B_(12)和葡萄糖酸钙锌口服液联合治疗手足口病后脱甲的临床疗效及可行性。方法:选取2016年10月至2017年12月佛山市三水区妇幼保健院收治的手足口病后脱甲患儿40例,按随机数字表法分为观察组和对照组,每组20例。对照组患儿给予常规治疗,观察组患儿在对照组基础上加用赖氨肌醇维生素B_(12)和葡萄糖酸钙锌口服液联合治疗。观察两组患儿脱甲停止时间、家属满意度、随访1个月的痊愈情况及不良反应发生情况。结果:观察组患儿平均脱甲停止时间为(15.8±4.8)d,明显短于对照组的(23.4±6.2)d,差异有统计学意义(P<0.05);观察组患儿家属的满意率为90%(18/20),明显高于对照组的50%(10/20),差异有统计学意义(P<0.05);随访1个月后,观察组患儿的痊愈率为80%(16/20),明显高于对照组的45%(9/20),差异有统计学意义(P<0.05);两组患儿不良反应发生率的差异无统计学意义(P>0.05)。结论:赖氨肌醇维生素B_(12)和葡萄糖酸钙锌口服液联合治疗手足口病后脱甲患儿的疗效显著,且安全性较好。

OBJECTIVE： To probe into the clinical efficacy and feasibility of lysine inositol vitamin B_（12） combined with calcium and zinc gluconates oral liquid in treatment of defluvium unguium of hand-foot-mouth disease（ HFMD）.METHODS： 40 child patients with defluvium unguium of HFMD admitted into Foshan Sanshui District Maternal and Child Health Care Hospital from Oct. 2016 to Dec. 2017 were selected and divided into observation group and control group via random number table,with 20 cases in each. The control group was given conventional therapy,while the observation group was given lysine inositol vitamin B_（12） combined with calcium and zinc gluconates oral liquid. Stopping time of defluvium unguium,family members＇ satisfaction,recovery rates in 1-month follow-up and incidences of adverse drug reactions of two groups were observed. RESULTS： The average stopping time of defluvium unguium of observation group was（ 15. 8 ± 4. 8） days,which was significantly shorter than that of the control group [（ 23. 4 ± 6. 2） days],with statistically significant difference（ P〈0. 05）. Family members＇ satisfaction of observation group was 90%（ 18/20）,which was significantly higher than that of the control group（ 50%,10/20）,with statistically significant difference（ P〈0. 05）. After 1-month follow-up,the recovery rate of observation group was 80%（ 16/20）,which was significantly higher than that of the control group（ 45%,9/20）,with statistically significant difference（ P〈0. 05）. There was no statistical significance in difference of incidences of adverse drug reactions between two groups（ P〉0. 05）.CONCLUSIONS： The efficacy of lysine inositol vitamin B_（12） combined with calcium and zinc gluconates oral liquid in treatment of defluvium unguium of HFMD is remarkable,with high safety.