摘要
目的:探讨抗菌药物用药频度(defined daily dose system,DDDs)与多重耐药鲍曼不动杆菌检出率之间的关系,为临床合理选用抗菌药物提供参考。方法:采用回顾性分析方法,对2016—2017年丹东市第一医院各季度抗菌药物的DDDs与同期多重耐药鲍曼不动杆菌检出率进行Pearson相关性分析。结果:含β-内酰胺酶抑制剂复方制剂、碳青霉烯类抗菌药物的DDDs与多重耐药鲍曼不动杆菌检出率之间的相关性有统计学意义,呈正相关(r分别为0.767、0.771,P分别为0.027、0.025);而其他类抗菌药物的DDDs与多重耐药鲍曼不动杆菌检出率之间的相关性无统计学意义。结论:抗菌药物的DDDs与鲍曼不动杆菌耐药存在相关性,提示临床应加强抗菌药物的合理应用,延缓和减少多重耐药鲍曼不动杆菌产生。
OBJECTIVE: To probe into the correlation between defined daily dose system( DDDs) of antibiotics and detection rate of multidrug-resistant acinetobacter baumannii,so as to provide reference for the rational drug use in clinic. METHODS: Retrospective analysis method was adopted,Pearson correlation analysis of DDDs of antibiotics and detection rate of multidrug-resistant acinetobacter baumannii were conducted from Dandong the First Hospital( hereinafter referred to as in each quarter during 2016-2017. RESULTS: DDDs of β-lactamase inhibitor combinations and carbopenems was positively correlated with detection rate of multidrug-resistant acinetobacter baumannii( r =0. 767,P = 0. 027; r = 0. 771,P = 0. 025). There was no significant correlation with other drugs. CONCLUSIONS:There is a correlation between the DDDs of antibiotics and the resistance of acinetobacter baumannii,which suggests that the rational use of antibiotics should be strengthened so as to delay and reduce the multidrug-resistant acinetobacter baumannii.
作者
孙盼盼
张宁
姜衍
SUN Panpan;ZHANG Ning;JIANG Yan(Dept.of Pharmacy,Dandong the First Hospital,Liaoning Dandong 118000,China;Dept.of Pharmaey,the Seeond Affiliated Hospital of Dalian Medieal University,Liaoning Dalian 116000,China)
出处
《中国医院用药评价与分析》
2018年第7期987-989,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
抗菌药物
用药频度
多重耐药鲍曼不动杆菌
检出率
相关性
Antibiotics
DDDs
Multidrug-resistant acinetobacter baumannii
Detection rate
Correlation