康复新液对比氨基水杨酸类药物治疗溃疡性结肠炎Meta分析

Meta-analysis of Kangfuxin Liquid versus Aminosalicylic Acid in Treating Ulcerative Colitis

目的：探讨康复新液对比氨基水杨酸类药物治疗溃疡性结肠炎的有效性,为其临床推广提供科学依据。方法：计算机检索中国生物医学文献数据库（CBM）,万方数据库,中国科技期刊全文数据库（VIP）,中国期刊全文数据库（CNKI）,Pub Med,The Cochrane Library和Embase数据库,收集康复新液治疗溃疡性结肠炎的随机对照试验,检索时间均为建库至2017年3月3日。由两名研究者按照纳入与排除标准独立筛选文献、提取资料并评价质量后,采用Rev Man5.3软件进行Meta分析。结果：共纳入9个RCT,806例患者。Meta分析结果显示,与氨基水杨酸类药物相比,康复新液可以显著提高治疗溃疡性结肠炎临床有效率[OR=3.12,95%CI（2.11,4.60）,P〈0.00001],并且能显著改善腹痛[OR=4.64,95%CI（2.12,10.14）,P=0.0001]症状,但不能显著改善腹泻[OR=1.89,95%CI（0.43,8.44）,P=0.40]、脓血便[OR=1.70,95%CI（0.80,3.60）,P=0.17]症状。结论：康复新液比氨基水杨酸类药物对溃疡性结肠炎有更好的疗效,但由于纳入文献质量较低,需要高质量的大样本双盲随机对照试验的支持。

Objective：To systematically evalutate the clinical efficacy of Kangfuxin Liquid versus aminosalicylic acid in treating ulcerative colitis,in order to provide scientific basis for clinical promotion. Methods： Databases such as CBM,Wan fang,VIP,CNKI,Pub Med,Cochrane Library and Embase were searched for randomized controlled trials about Kangfuxin Liquid versus aminosalicylic acid as the interventions for ulcerative colitis from database creation to March 3 th,2017. Two researchers independently screened the literature,extracted the data and evaluated methodological quality according to the inclusion and exclusion criteria.Rev Man 5. 3 was used to revaluate the results of the total effect of Meta-analysis. Results：Nine RCTs involving 806 patients were included into the study. The Meta-analysis results showed that compared with aminosalicylic acid,Kangfuxin Liquid can significantly improve the clinical effective rate[OR = 3. 12,95% CI（ 2. 11,4. 60）,P〈0.00001 ],improve abdominal pain symptoms[OR = 4. 64,95% CI（2. 12,10. 14）,P = 0. 0001],but can not significantly improve diarrhea[OR = 1. 89,95% CI（0. 43,8.44）,P = 0. 40],pus and blood stools[OR = 1. 70,95% CI（0. 80,3. 60）,P = 0. 17]. Conclusion：Compared with aminosalicylic acid,Kangfuxin Liquid shows better effect on treating ulcerative colitis. However,due to the low methodology,more high-quality double-blind trials with a large sample size are required to support this conclusion.