宝鸡市2010—2016年无偿献血者核酸检测结果分析

Nucleic acid test(NAT) result analysis of the voluntary blood donors in Baoji during 2010 to 2016

目的分析宝鸡市无偿献血者核酸检测结果,为无偿献血招募和进一步降低经血传播疾病提供依据。方法收集2010年10月1日—2016年12月31日宝鸡市无偿献血者核酸检测数据,进行统计分析。结果 2010—2016年核酸检测标本185 197份,141例呈HBV DNA有反应性,检出率为0.076%（141/185 197）;未检出HCV RNA和HIV RNA;混样有反应性标本主要集中在35≤CT值〈39（55.92%）,这个区间拆分有反应性的占比最多（64.54%,91/141）;本市NAT（nucleic acid test）有反应性献血者以男性为主（75%）、年龄43—55岁居多（60%）、职业多为农民（42%）、学历以初高中为主（92%）。结论核酸检测可以有效降低输血的残余风险;NAT混样有反应性标本主要集中在35≤CT值〈39（55.92%,151/270）,NAT拆分有反应性标本主要集中在CT值〈37（79.43%,112/141）;针对本市NAT有反应性献血者以男性农民年龄43—55岁、学历以初高中为主的特征,从18—43岁女性、非农民组、高学历人群中招募献血者,能最大程度保证血液安全。

Objective To analyze the test results and provide valuable reference data for the improvement of donation recruitment and reduced risks of blood-transmitted diseases. Methods The NAT data from Oct 1 st,2010 to Dec 31 th,2016 were collected and analyzed. Results A total of 185 197 NAT cases were processed from 2010 to 2016,with 141 HBV-reactive cases at a detection rate of 0. 076%（ 141/185 197）; No HCV/HIV-reactive samples were detected; The reactivie samples were mainly detected from mixed pools with CT values between 35 and 39（ 55. 92%） at a reactive proportion of 64. 54%（ 91/141）; Male donors accounted for the main portion of reactive donors（ 75%）.Donors aged 43—55（ 60%） and donors with limited education background（ 92%）（ primary/high school） were also the main factors related to sample reactivity.Conclusion NAT analysis can effectively reduce the residual risk in blood transfusion; Samples with CT values below 37 ought to be the main focus in NAT screening tests,which accounted for the main body of reactive donors in our study（ 79. 43%,112/141）; According to the factor analysis,recruiting from female donors aged between 18—43 with higher education background may help to reduce blood safety issues.