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复发性自然流产患者血浆D-二聚体、抗凝血酶Ⅲ和蛋白C检测的临床意义 被引量:18

Detection and Analysis of D-Dimer,Antithrombin Ⅲ and Protein C in Patients with Recurrent Spontaneous Abortion
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摘要 目的探讨复发性自然流产(RSA)患者孕早期的D-二聚体(D-Dimer)、抗凝血酶Ⅲ(AT-Ⅲ)和蛋白C(PC)变化的临床意义。方法选取150例有RSA病史且早孕的患者作为RSA组,其中根据流产的次数分为RSAⅠ组94例(流产次数2~3次)和RSAⅡ组56例(流产次数≥4次),另外选择100例健康且无流产史的早孕孕妇作为正常早孕组。对上述各组患者进行D-Dimer,AT-Ⅲ和PC的检测和对比分析。结果 RSA组和正常早孕组的D-Dimer,AT-Ⅲ和PC的结果分别为1.67±0.35mg/L vs 0.37±0.29 mg/L,(84.57±10.88)%vs(99.28±9.01)%和(82.63±11.32)%vs(100.26±10.61)%,差异均有统计学意义(t=8.21,7.87,7.97,均P<0.01);RSAⅡ组和RSAⅠ组上述各参数比较结果分别为(1.84±0.31)mg/L vs(1.53±0.37)mg/L,(80.48±9.87)%vs(88.62±11.23)%和(79.89±11.64)%vs(86.77±12.78)%,差异均有统计学意义(t=3.86,4.31,4.50,均P<0.05)。结论 RSA患者在孕早期血栓形成的风险比正常孕妇高,且与既往的流产次数有一定的相关,D-Dimer,AT-Ⅲ和PC的检测对RSA患者血栓状态的筛查和改善妊娠结局有重要的临床意义。 Objective To investigate the changes of D-Dimer(D-Dimer),antithrombin III(AT-III)and protein C(PC)in the early pregnancy of recurrent spontaneous abortion(RSA).Methods A total of 100patients with a history of RSA and early pregnancy patients as RSA group,according to the number of miscarriages were divided into RSA groupⅠ64cases(abortion 2~3times)and RSAⅡGroup 36cases(abortion more than 4times),another 100healthy pregnant and no history of abortion as a normal pregnancy group.Detection and analysis of D-Dimer,AT-Ⅲand PC in all the above groups were done.Results The results of D-Dimer,AT-Ⅲand PC in group RSA and normal pregnancy group were(1.67+0.35)mg/L vs(0.37+0.29)mg/L,(84.57+10.88)%vs(99.28+9.01)%and(82.63+11.32)%vs(100.26+10.61)%respectively,and the difference was statistically significant(t=8.21,7.87,7.97,all P〈0.01).The results of the above parameters in group RSAⅡand RSAⅠwere(1.84+0.31)mg/L vs(1.53+0.37)mg/L,(80.48+9.87)%vs(88.62+11.23)%and(79.89+11.64)%vs(86.77+12.78)%respectively,and the differences were statistically significant(t=3.86,4.31,4.50,all P〈0.05).Conclusion The risk of thrombosis in RSA patients was higher than that of normal pregnant women in early pregnancy,and had a certain correlation with the number of previous abortions.The detection of D-Dimer,AT-Ⅲand PC has important parturient value for screening RSA patients and improving pregnancy outcomes.
作者 吴剑锋 WU Jian-feng(Department of Clinical Laboratory,Nanhai Maternity and Child Health Care Hospital of Foshan,Guangdong Foshan 528200,China)
出处 《现代检验医学杂志》 CAS 2018年第4期112-114,共3页 Journal of Modern Laboratory Medicine
关键词 复发性自然流产 D-二聚体 抗凝血酶Ⅲ 蛋白C recurrent spontaneous abortion D-Dimer antithrombin Ⅲ protein C
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