卒中后认知功能障碍患者血清低密度脂蛋白胆固醇测定的临床意义

Clinical Significance of Serum Low Density Lipoprotein Cholesterol of Patients with Post-Stroke Cognitive Impairment

目的探讨测定血清低密度脂蛋白胆固醇(serum low density lipoprotein cholesterol,LDL-C)与卒中后认知功能障碍(post-stroke cognitive impairment,PSCI)及其严重程度的相关性。方法采用病例对照研究,选择2013年1月~2016年12月期间武警陕西省总队医院门诊及住院的PSCI患者68例作为研究对象,依据简易智力量表检测以及蒙特利尔认知评分检测结果,分为2组,其中轻度组(45例)和中重度组(23例),并选择同期在该院体检中心体检,体检结果各项指标均正常者70例为对照组。比较两组血清LDL-C水平及不同程度PSCI患者血清LDL-C水平。结果 PSCI病例组血清LDL-C水平为3.42±0.26mmol/L,正常对照组为2.16±0.31 mmol/L,组间比较差异有统计学意义(t=-2.532,P=0.008);中重度PSCI组的血清LDL-C水平为3.61±1.39mmol/L,轻度组为3.12±0.38mmol/L,组间比较差异有统计学意义(t=-2.240,P=0.014)。结论血清LDL-C水平是PSCI的重要危险因素,其水平可反映PSCI患者病情的严重程度。

Objective To investigate the correlation between the serum low density lipoprotein cholesterol（LDL-C）and the post-stroke cognitive impairment（PSCI）and its severity.Methods Case-control studies were used.68 patients with PSCI were admitted in the Cardre Wards of the Shaanxi Provincial Armed Police Corps Hospital,ranging from January 2013 to December 2016.According to the testing result of simple Intelligence Scale and Montreal Cognitive Score,the patients were divided into the mild cognitive impairment and the moderate and severe cognitive impairment.70 healthy controls at the same time were as the control group.Compared the serum LDL-C level between the two groups and compared the serum LDL-C level with different severity of PSCI.Results The levels of serum LDL-C of the patients with PSCI was 3.42±0.26 mmol/L,and the control group was 2.16±0.31 mmol/L.It had statistical difference between the two groups（t=-2.532,P=0.008）.The serum LDL-C of patients with the moderate and severe cognitive impairment group was 3.61±1.39 mmol/L,and the mild group was 3.12±0.38 mmol/L.It had statistical difference between the two groups（t=-2.240,P=0.014）.Conclusion The levels of serum LDL-C is the important risk factor of the PSCI,and the levels of serum LDL-C can be responsed the severity of the patients with PSCI.