黑皮质素受体4在能量调节及肥胖中的作用

Role of melanocortin receptor-4 in energy regulation and obesity

肥胖作为一种流行性代谢性疾病，已成为危害人类健康的世界性问题。体重的改变反映机体内部能量失衡，而中枢和外周黑皮质素系统的稳态调节恰可维持能量平衡从而影响体重。近来研究发现，黑皮质素受体4（MC4R）在能量稳态调节和体重改变中发挥重要作用，但其具体机制仍有待进一步阐明。本文主要就MC4R在体重调节和能量平衡方面的研究进展进行综述，为进一步探讨MC4R在能量代谢失衡及肥胖中的潜在作用提供理论依据。

As a pandemic metabolic disease, obesity has become a worldwide problem, which endangering human health. The change in body weight reflects the energy imbalance. And the homeostasis regulation of the central and peripheral melanocortin system may maintain the energy balance and then affect the body weight. Recent studies have found that melanocortin receptor-4 （MC4R） plays an important role in energy homeostasis and body weight changes, but its specific mechanism needs further elucidation. In this paper, we reviewed the research progress of MC4R in body weight and energy regulation, so as to provide a theoretical basis for further exploring the potential role of MC4R in improving energy metabolism imbalance and obesity.