静脉溶栓后发生早期神经功能恶化研究进展

Current situation and prospect of intravenous thrombolytic therapy for acute ischemic stroke

静脉溶栓是急性缺血性卒中患者早期最有效的治疗方法,但相当一部分患者溶栓治疗后出现早期神经功能恶化(END),症状进一步加重。目前学术界对于END的定义尚未统一,因此导致END的发生率不尽相同。关于END确切病因、危险因素以及相关病理生理机制仍是学术界讨论的热点。END的发生强烈提示患者3个月预后不良。文章就以上内容进行综述。

Intravenous thrombolysis is the most effective treatment in patients with acute ischemic stroke, but some patients have early neurological deterioration（END） after thrombolysis. At present, the definition ofEND has not been standardized in the academic world, so the incidence of END can not be accurately assessed.The exact etiology, risk factors and pathophysiological mechanism of END are still the focus of academic discussion. The occurrence of END strongly suggests a poor prognosis at 3 months.The article reviews the above.