持续负压吸引联合臭氧治疗对高位肛瘘术后伤口愈合的疗效分析

The effect analysis of combination negative pressure wound and ozone therapy in postoperative wound of high anal fistula patients

目的分析持续负压吸引联合臭氧治疗技术应用于高位肛瘘患者术后创面,探讨其对术后伤口愈合的临床效果。方法收集2015―2016年该院收治的60位高位肛瘘患者分为3组,实验组(n=20)经过肛瘘切除后采用持续负压吸引联合臭氧治疗,对照组(n=20)经过肛瘘切除后采用单纯持续负压吸引治疗,另外20例患者经肛瘘切除联合伤口换药作为空白组,综合评估3组患者的愈后情况,具体包括愈合时间、愈合率、视觉模拟疼痛(VAS)评分、肛功能评分等,并通过Kaplan-Meier分析3组患者伤口愈合生存时间。结果实验组患者肛瘘术后伤口愈合率明显高于对照组和空白组,伤口生存时间明显低于对照组和空白组;实验组患者术后痛感、肛功能评分和复发率均低于对照组和空白组,差异均有统计学意义(P<0.05)。结论持续负压吸引联合臭氧治疗技术可显著提高高位肛瘘患者伤口愈合率,缩短伤口愈合时间,保护肛门功能,具有重要临床意义。

Objective Negative pressure wound therapy （NPWT） combined ozone therapy would be applied to the postoperative wound of high anal fistula patients,and the clinical effect of wound healing was observed. Methods We enrolled 60 patients with high anal fistula from 2015 to 2016 and assigned to three groups including 20 treated with anal fistulectomy combined NPWT＋ozone,20 treated with anal fistulectomy combined NPWT and 20 treated with anal fistulectomy combined wound dressing.The following indexes in three groups were compared and analyzed,including wound healing time,wound healing rate,postoperative pain score and anal function score.The Kaplan-Meier analysis was performed to evaluate the survival time of wound healing in the all groups. Results The wound healing rate in experimental group was higher than that in control and blank group.The level of survival time of wound healing in experimental group was under that in control and blank group.And the level of postoperative pain score,anal function score and recurrence rate in the experimental group significantly decreased compared to the control and blank group （all P 〈0.05）. Conclusion Negative pressure wound therapy combined ozone therapy could significantly improve the wound healing rate in high anal fistula patients,reduce the wound healing time and protect the anal function,which showed lots of important clinical significance.