脉络学说构建及其指导血管病变防治药物的研究

Construction of collateral theory and its guidance on preventive and therapeutic medication for vascular diseases

根据中医理论发展规律,系统构建了指导血管病变防治的脉络学说。该学说基于气—阴阳—五行理论,提出其核心理论——"营卫承制调平",经过一系列基础和临床研究,其科学内涵进一步得到佐证。提出"微血管损伤"为急性心肌梗死、脑梗死、糖尿病微血管病变的共性核心机制,在脉络学说的指导下以"搜剔疏通"为组方特色研制的治疗冠心病、心绞痛的药物通心络胶囊,在保护血管内皮、稳定易损斑块、缓解血管痉挛等方面表现出了良好的疗效,可有效治疗上述病变;参松养心胶囊在治疗心律失常方面显示出了快慢兼治、整合调节的优势;芪苈强心胶囊对于慢性心力衰竭标本兼治。这些研究均显示出脉络学说指导下的通络创新药物在防治血管系统疾病方面的优势,对提高对这类严重危害人类健康的重大血管疾病的防治水平具有重要的临床意义。

Following the development law of traditional Chinese medicine theory,the collateral theory has been constructed to instruct the prevention and treatment of vascular diseases.Based on the theory of ＂qi-yin-yang-fiveelements＂,collateral theory proposes its essential idea of ＂Yingwei Chengzhi Tiaoping＂,which refers to the selfstabilizing and regulation mechanism of vascular endothelium and adventitia.A series of fundamental and clinical research further supports its scientific connotation.The theory defines＂microvascular injury＂as the common core mechanism of acute myocardial infarction,cerebral infarction and diabetic microangiopathy.Tongxinluo capsule is developed targeting to cure coronary heart disease and angina pectoris.It is effective in protecting blood vessel endothelium,stabilizing vulnerable plaque and relieving angiospasm,and thus treating the above diseases.In the guidance of collateral theory,its prescription is composed featured by ＂Souti Shutong＂referring to seeking and screening vessel from the collateral system to dredge it.Shensong Yangxin capsule takes advantages in treating arrhythmias,featured by simultaneously treating tachyarrhythmia and bradycardia as well as making integrated regulation.Qili Qiangxin capsule can thoroughly treat chronic heart failure.In the field of preventing and treating vascular diseases,the superiority of collateral-theory-guided Tongluo innovative medicine is revealed by all the research.It has significant clinical value to raise the control level of critical vascular diseases endangering human health.