促排前不同预处理及促排卵方案影响肥胖型多囊卵巢患者妊娠结局的研究进展

Research progress on effects of different preconditioning treatment and ovulation induction protocols on patients with obesity-type polycystic ovary

多囊卵巢综合征(PCOS)是一种生殖功能障碍以及糖代谢异常等为特征的内分泌紊乱综合征,基本特征为长期不排卵或稀发排卵、卵巢多囊性增大、高雄激素血症,常伴有胰岛素抵抗、糖脂代谢异常等,在临床以及公共卫生方面有显著影响,很多育龄妇女受其影响。PCOS的诊断目前多以鹿特丹标准为主。促排前的预处理是肥胖型PCOS患者的治疗方法之一,但预处理是否必要尚有争议,同时超促排方案的选择也有争议。本文对肥胖型PCOS患者促排卵前的不同预处理及不同促排方案进行综述。

Polycystic ovary syndrome（PCOS）is an endocrine disorder syndrome characterized by reproductive dysfunction and abnormal glucose metabolism.It is characterized by long-term anovulation or sparse ovulation,polycystic ovarian enlargement,and hyperandrogenism,often accompanied by insulin resistance,abnormal glucose and lipid metabolism,etc.PCOS has a significant impact on clinical and public health,with up to one-fifth of women of childbearing age are affected.The diagnosis of PCOS is currently dominated by Rotterdam standards.Preconditioning before ovulation induction is one of the treatment methods for obese PCOS patients,whether preconditioning is necessary is still controversial.Meanwhile,the choice of super-induced ovulation protocol is also controversial.This article reviews the different preconditioning methods and different ovulation induction protocol in obese PCOS patients.