参芎葡萄糖联合阿司匹林和氯吡格雷治疗不稳定型心绞痛的疗效观察

Effect observation of Shenxiong Glucose Injection combined with Aspirin and Clopidogrel in the treatment of unstable angina pectoris

目的观察参芎葡萄糖注射液(佰塞通)联合阿司匹林及氯吡格雷治疗不稳定型心绞痛(UAP)的疗效。方法 120例不稳定型心绞痛患者,随机分为对照组和观察组,每组60例。对照组在常规治疗基础上给予阿司匹林及氯吡格雷,观察组在对照组基础上给予静脉输注佰塞通。观察比较两组的心绞痛疗效、心电图疗效、不良反应及心血管事件的发生情况。结果观察组患者的心绞痛治疗总有效率为95.0%,显著高于对照组的83.3%,差异具有统计学意义(P<0.05)。两组心电图治疗总有效率比较,差异有统计学意义(P<0.05)。观察组心血管事件发生率显著低于对照组,差异有统计学意义(P<0.05)。两组出血发生率比较差异无统计学意义(P>0.05)。两组患者未见其他不良反应。结论佰塞通联合阿司匹林及氯吡格雷治疗不稳定型心绞痛,可明显提高临床疗效。

Objective To investigate the effect of Shenxiong Glucose Injection（Baisaitong） combined with Aspirin and Clopidogrel in the treatment of unstable angina pectoris（UAP）. Methods A total of 120 patients with UAP were randomly divided into control group and observation group, 60 cases in each group. The control group was treated with Aspirin and Clopidogrel on the basis of conventional therapy, the observation group was treated with Baisaitong for intravenous infusion on the basis of control group. The efficacy of angina pectoris and electrocardiogram, adverse reactions and cardiovascular events were observed and compared between the two groups. Results The total effective rate of angina pectoris in the observation group was 95.0%, which was significantly higher than 83.3% in the control group, the difference was statistically significant（P〈0.05）. The total effective rate of electrocardiogram treatment between the two groups was statistically significant（P〈0.05）. The incidence of cardiovascular events in the observation group was significantly lower than that in the control group, the difference was statistically significant（P〈0.05）. There was no significant difference in the incidence of hemorrhage between the two groups（P〉0.05）. No other adverse reactions were found in the two groups. Conclusion Baisaitong combined with Aspirin and Clopidogrel in the treatment of UAP can significantly improve the clinical efficacy.