Pluronic载体在抗肿瘤聚合物胶束的研究进展

Advances of Anti-tumor Polymeric Micelles by Pluronic Carrier

多药耐药性是近年来癌症化疗失败的主要原因,药物传递系统为逆转肿瘤细胞的多药耐药性提供了一条有效途径。以Pluronic为载体的聚合物胶束由于其自身具有可以逆转MDR的特性,作为一种新型抗肿瘤药物传递系统备受关注。本文主要对Pluronic的生物特性、逆转MDR的机制及药物载体功能进行综述。

Drug delivery system provides an effective way to reverse multidrug resistance （MDR） which is one of the main reasons of cancer chemotherapy failure in recent years. Among lhem, lhe polymeric mieelles of pluronie as a new anti-tumor drug delivery system al- tract much attention because of their unique properties of reversing MDR. In this paper reviewed were the biological characteristics, the mechanism of reversing MDR, and the function of drug carrier of Pluronie.