FOLFOX方案联合营养支持治疗胃肠道恶性肿瘤的临床效果分析

Clinical Efficacy of FOLFOX Chemotherapy Combined with Nutritional Support in the Treatment of Gastrointestinal Malignancies

目的观察FOLFOX方案联合营养支持治疗胃肠道恶性肿瘤的临床效果。方法选取我科收治的64例胃肠道恶性肿瘤患者作为研究对象,随机分为观察组(34例)和对照组(30例)。两组患者均采用FOLFOX化疗方案进行治疗,对照组采用常规FOLFOX化疗后干预措施,观察组在此基础上给予营养支持。统计分析两组患者的近期疗效、不良反应及营养指标变化情况。结果治疗后两组患者的近期疗效和不良反应发生率比较,差异无统计学意义(P>0.05),观察组患者的营养评分、体重、BMI指数、白蛋白(ALB)和血红蛋白(Hb)均优于对照组(P<0.05)。结论 FOLFOX方案联合营养支持治疗胃肠道恶性肿瘤,尽管不能提高患者的近期疗效,但可有效改善患者的营养状况,降低营养风险。

Objective To observe the clinical effects of FOLFOX chemotherapy combined with nutritional support for gastrointestinal malignancies. Methods Sixty-four patients with gastrointestinal malignancies admitted to our hospital were randomly divided into the ob- servation group （34 cases） and the control group （30 cases）. Both groups were treated with FOLFOX chemotherapy. The control group was treated with conventional intervention after FOLFOX chemotherapy, while the observation group was added with nutrition support. The short-term efficacy, adverse reactions, and changes in nutritional indicators were statistically analyzed. Results There was no significant difference between the two groups in the short-term efficacy and adverse reactions （P 〉 0.05）. However, the nutritional status, body weight, BMI index, albumin （ALB） and hemoglobin （Hb） of patients in the observation group were all better than in the control group （P 〈 0.05）. Conclusion The application of FOLFOX chemotherapy plus nutritional support in the treatment of gastrointestinal cancer can improve the patient＇ s nutritional status and reduce nutritional risk.