摘要
目的探讨EGFR基因突变与肺腺癌患者的临床特征、病理类型之间的关系,为临床预测EGFR基因突变状态提供依据。方法回顾性分析2016年6月至2017年6月在郑州大学第一附属医院胸外科经手术切除确诊肺腺癌并行EGFR基因检测的患者资料,有效纳入269例患者。比较突变组与野生组患者性别、年龄、吸烟史、高血压病史、糖尿病史、血型及病理类型之间相关性。结果 269例肺腺癌患者中EGFR基因突变者165例(占61.3%)。突变组和野生组在性别、吸烟史、病理类型方面差异有统计学意义(P<0.05)。两组年龄、高血压病史、糖尿病史、血型差异无统计学意义(P>0.05)。结论肺腺癌中EGFR基因突变多见于女性、非吸烟患者;浸润型腺癌、腺鳞癌突变率较高,黏液型腺癌和肠型腺癌突变率较低。
Objective To explore the relationship between EGFR gene mutation and lung adenocarcinoma patients with clinical features and pathological types,and provide a basis for better prediction of EGFR gene mutation status in patients.Methods Two hundred sixty-nine patients with confirmed lung adenocarcinoma and concurrent EGFR gene detection were retrospectively analyzed in June of 2016 to June of 2017 in the First Affiliated Hospital of Zhengzhou University. The differences in gender,age,smoking history,history of hypertension,history of diabetes,blood type and pathological type were compared between the mutant group and the wild group. Results One hundred and sixty-five cases( 61. 3%) of EGFR gene mutation in269 patients. There was a statistical significant difference in gender,smoking history,and pathological types between the mutant and wild groups( P〈0. 05). There was no significant difference in age,history of hypertension,history of diabetes,and blood group between two groups( P〉 0. 05). Conclusion EGFR gene mutations in lung adenocarcinoma are more common in females and non-smokers. Mutations in invasive adenocarcinomas and adenosquamous carcinomas are more frequent,and mucinous adenocarcinomas and intestinal adenocarcinomas have lower mutation rates.
作者
陈小放
付校
王文涛
刘帅帅
崔广晖
Chen Xiaofang;Fu Xiao;Wang Wentao;Liu Shuaishuai;Cui Guanghui(Department of Thoracic Surgery,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《河南医学研究》
CAS
2018年第11期1949-1951,共3页
Henan Medical Research
关键词
EGFR基因
肺腺癌
临床特征
病理类型
EGFR gene
lung adenocarcinoma
clinical feature
pathologic type