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Ndc80复合体在肿瘤中的研究进展

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摘要 核分裂周期蛋白80(nuclear division cycle 80,Ndc80)复合体是一种异四聚体蛋白复合物,在细胞有丝分裂过程中起着重要作用[1]。Ndc80复合体异常表达会引起染色体异常分离,导致基因组的不稳定,基因组不稳定性是所有肿瘤发生的主要因素[2]。大量研究发现,Ndc80复合体各组件在肿瘤中高表达,其可作为某些肿瘤的诊断标志物,甚至可能成为评估预后的指标。
出处 《河南医学研究》 CAS 2018年第14期2550-2551,共2页 Henan Medical Research
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