血尿酸水平与2型糖尿病慢性并发症的关系研究

Research on the relationship of serum uric acid level and chronic complications of type 2 diabetes mellitus

目的探讨血尿酸(UA)水平与2型糖尿病慢性并发症的关系,为其临床防治提供理论依据。方法回顾性分析240例2型糖尿病患者的临床资料,所有患者入院后均行UA检测,分析其与2型糖尿病慢性并发症的关系。结果随着UA水平的升高,糖尿病周围神经病变(DPN)的发生率先降低后升高,差异有统计学意义(P<0.05)。当UA<340μmol/L且≥270μmol/L时,DPN发生率最低。随着UA水平的升高,糖尿病周围血管病变(PVD)、糖尿病视网膜病变(DR)、糖尿病肾病(DN)的发生率差异无统计学意义(P>0.05)。结论 UA水平与DPN的发生相关,但与PVD、DN、DR的关系有待进一步研究,对于2型糖尿病患者可以将UA作为常规的检测指标,对于未达标者通过饮食控制,必要时药物干预等方法将其控制在适当范围,有助于改善患者的长期预后。

Objective To investigate the relationship between serum uric acid（UA） level and chronic complications of type 2 diabetes mellitus, to provide theoretical basis for its clinical prevention and treatment.Methods Clinical data of 240 patients with type 2 diabetes mellitus were retrospectively analyzed. The blood UA levels were detected in all patients after admission, the relationship between them and chronic complications of type 2 diabetes mellitus was observed.Results The incidence of diabetic peripheral neuropathy（DPN） decreased first and then increased with the increase of UA level, the difference was statistically significant （ P 〈0.05 ）,and the incidence of DPN was lowest when 270 μmol/L≤UA〈340 μmol/L. With the increase of UA level, the incidence of peripheral vascular disease（PVD）, diabetic retinopathy（DR）, diabetic nephropathy（DN） had no statistically significant differences（ P 〉0.05 ）.Conclusion The level of UA is associated with the incidence of DPN, but the relationship with the incidence of PVD, DN and DR need further study. For patients with type 2 diabetes mellitus, routine monitoring of UA levels, and controlling it in appropriate areas through diet and medication can contribute to their long-term prognosis.