血清PCT、hs-CRP及PA在老年肺部感染患者中的临床诊断价值

Clinical Diagnostic Value of Serum PCT, hs-CRP and PA in Elderly Patients with Pulmonary Infection

探讨血清中PCT、hs-CRP及PA联合检测诊断老年肺部感染的临床价值。选取2015年1月至2017年1月本院收治的150例老年肺部感染患者,根据病情分为重症感染组70例和一般感染组80例,选取同期健康老年人80例作为对照组,通过检测各组老年人血清中降钙素原（PCT）、超敏C反应蛋白（hs-CRP）及前白蛋白（PA）水平,并采用ROC曲线分析这三种指标的联合检测对老年人肺部感染诊断的价值。结果显示,治疗前,重症感染组的PCT、hs-CRP水平明显高于一般感染组和对照组（p〈0.05）,重症感染组的PA水平则明显低于一般感染组和对照组（p〈0.05）;一般感染组的PCT、hs-CRP水平明显高于对照组（p〈0.05）,一般感染组的PA水平则明显低于对照组（p〈0.05）;治疗2周后,重症感染组的PCT、hs-CRP水平明显高于一般感染组和对照组（p〈0.05）,重症感染组的PA水平显著低于一般感染组和对照组（p〈0.05）。根据ROC曲线分析,老年重症肺部感染组PCT、hs-CRP及PA的AUC分别为0.849、0.784和0.761,其中PCT的鉴别效果最好,当OOP为2.5 ng/m L时,对应的灵敏度为83.16%、特异度为87.41%。本研究表明老年肺部感染患者血清中PCT、hs-CRP是明显增高的,而PA水平则明显降低,联合检测血清中PCT、hs-CRP及PA的水平对于老年肺部感染患者的鉴别诊断具有一定的临床价值,其中PCT的诊断价值更高。

To explore the clinical value of combined detection of serum PCT, hs-CRP and PA in diagnosing elderly patients with pulmonary infection. From January 2015 to January 2017, 150 elderly patients with pulmonary infection were selected and divided into 70 patients with severe infection and 80 patients with general infection according to their condition. 80 healthy elderly patients were selected as the control group. The serum levels of procalcitonin（PCT）, high-sensitivity C-reactive protein（hs-CRP）, and prealbumin（PA） were measured in elderly patients in each group, and the combined detection of these three indexes was performed on the elderly lung using the ROC curve. The value of the diagnosis of infection. The results showed that before trea tment, the PCT and hs-CRP levels in the severe infection group were significantly higher than those in the general infection group and the control group（p〈0.05）. The PA level in the severe infection group was significantly lower than that in the general infection group and the control group（Clinical Diagnostic Value of Serum PCT, hs-CRP and PA in Elderly Patients with Pulmonary Infection（p〈0.05）; The PCT and hs-CRP levels in the general infection group were significantly higher than those in the control group（p〈0.05）. The PA level in the general infection group was significantly lower than that in the control group（ p〈0.05）. After 2 weeks of treatment, the severe infection group The levels of PCT and hs-CRP were significantly higher in the normal infection group and the control group（p〈0.05）. The PA level in the severe infection group was significantly lower than that in the general infection group and the control group（p〈0.05）. According to ROC curve analysis, the AUC of PCT, hs-CRP, and PA in elderly patients with severe pulmonary infection were 0.849, 0.784, and 0.761, respectively. The PCT had the best discriminating effect.When the OOP was 2.5 ng/m L, the corresponding sensitivity was 83.16. The specificity was 87.41%. This study showed that serum PCT and hs-CRP were significantly increased in elderly patients with pulmonary infection,while PA levels were significantly lower. Combined detection of serum PCT, hs-CRP and PA levels in the differential diagnosis of elderly patients with pulmonary infection Certain clinical values, of which the diagnostic value of PCT is higher.