头孢哌酮舒巴坦治疗脓毒血症可有效降低患者的炎症因子、Pro-ADM、MIF水平

Cefoperazone Sulbactam in Treatment of Sepsis can Effectively Reduce the Levels of Inflammatory Factors, Pro-ADM and MIF

本研究为分析头孢哌酮舒巴坦对脓毒血症患者血清炎症因子变化、临床治疗效果及护理对策,选取了102例自2016年1月至2017年4月我院收治的脓毒血症患者,将研究对象根据治疗方法不同分为对照组和观察组各51例进行研究。对照组患者采用常规对症治疗,观察组患者在对照组的基础上联合头孢哌酮舒巴坦进行治疗,分析两组患者治疗后的临床疗效。治疗前,两组患者IL-1、IL-1β、PCT、CRP、NT-pro BNP、Pro-ADM、MIF水平比较无统计学差异（p〉0.05）,治疗后,观察组患者IL-1、IL-1β、PCT、CRP、NT-pro BNP、Pro-ADM、MIF水平低于对照组（p〈0.05）;两组患者治疗前后免疫功能指标水平比较均无统计学差异（p〉0.05）;治疗前,两组患者APACHEII评分比较无统计学差异（p〉0.05）,治疗后,观察组患者APACHEII评分优于对照组（p〈0.05）。研究表明头孢哌酮舒巴坦治疗脓毒血症疗效显著,可降低患者炎症因子、Pro-ADM、MIF水平,同时对机体免疫功能影响较小,安全性较高。

This research is for the purpose of analyzing the effect of cefoperazone sulbactam on serum inflammatory factors in patients with sepsis. The research team had retrospectively chosen 102 patients with sepsis from January 2016 to April 2017. The patients were divided into control group and observation group according to different treatment methods, each group had 51 patients. The patients in control group were treated with routine symptomatic therapy. The patients in the observation group were treated with Cefoperazone sulbactam on the basis of routine symptomatic treatment. Before treatment, there was no significant difference in the level of IL-1, IL-1βand CRP, NT-pro BNP, Pro-ADM and MIF between two groups（p〉0.05）. After treatment the level of IL-1, IL-1βand CRP, NT-pro BNP, Pro-ADM and MIF of observation group was lower than that of control group（p〈0.05）.There was no significant difference in the level of immune function between the two groups before and after treatment（p〉0.05）. Before treatment, there was no significant difference in APACHEII score between the two groups（p〉0.05）. After treatment, the APACHEII score in the observation group was better than that in control group（p〈0.05）. This research had shown that Cefoperazone sulbactam has a significant therapeutic effect on sepsis,which can reduce the level of Pro-ADMN MIF in patients with sepsis, but has little effect on immune function, as had high security.