肿瘤微环境与前列腺癌骨转移研究进展

Research Progress of Tumor Microenvironment and Prostate Cancer Bone Metastasis

前列腺癌(prostate cancer,PCa)转移中大约80%是发生骨转移,是造成患者死亡的主要原因。前列腺癌骨转移主要呈现成骨和破骨混合性损伤。然而,诱发肿瘤细胞转移到骨以及引起混合样病变的机制仍不十分清楚。宿主微环境与前列腺癌细胞间的相互作用是其中一个重要原因。本文主要讨论宿主微环境如何影响前列腺癌骨转移各个阶段的发生及其中的机制,探讨多种细胞因子、分泌蛋白、微环境中的免疫细胞、成骨细胞、破骨细胞等分泌的因子在前列腺癌骨转移中的重要作用。

The majority of prostate cancer（PCa）-induced deaths is due to the development of metastatic disease, 80% of which is primarily localized in the bone. The types of bone metastasis of PCa are mainly osteoblastic or osteoclastic lesions. What triggers PCa metastasis to the bone and what causes osteoblastic and osteoclast lesions remain unanswered. A major contributor to PCa metastasis is the host microenvironment. Here, we mainly discuss how primary tumor microenvironment affects the occurrence and mechanism of bone metastasis in prostate cancer. The mechanisms and effects of secretory factors, secretory proteins, immune cells, osteoblasts, osteoclasts and other secreted factors on bone metastasis of prostate cancer will be discussed and summarized.