循环标志物早期诊断肺癌研究进展

Research progress of circulating markers in early diagnosis of lung cancer

肺癌的早期临床诊断目前缺少敏感度和特异度较高的筛查手段，而通过检测血液样本中的循环标志物来诊断肺癌提供了一种低侵袭的方法，并且能克服肿瘤异质性，实现肿瘤变化的实时监测，最终有望改变肺癌的早期诊断和预后。本文就近年来循环肿瘤细胞、循环miRNA、循环肿瘤DNA、循环蛋白质以及循环外泌体的研究进展进行综述。

Now in the early diagnosis of lung cancer lacks screening methods with higher sensitivity and specificity. A new low-invasive method by testing circulating markers of blood sample can overcome tumor heterogeneity, achieve real-time monitoring of tumor change, and finally change early diagnosis and prognosis of lung cancer. This paper focuses on research progress of circulating tumor cell, circulating miRNA, circulating tumor DNA, circulating proteins and circulating exosomes.