静息态f MRI在阻塞性睡眠呼吸暂停综合征中的应用

Application of Resting State fMRI in the Study of Obstructive Sleep Apnea Syndrome

阻塞性睡眠呼吸暂停综合征(OSAS)是一种多见的睡眠结构紊乱性疾病。睡眠过程中重复呼吸暂停或低通气,致使夜间的窒息和觉醒,反复的低氧血症、高碳酸血症和睡眠构造的片段化,造成白天嗜睡,是可以影响全身各器官的一种疾病。近年来,功能磁共振成像(functional MRI,fMRI)为OSAS的发病机制的研究提供了一种新的评价途径。基于静息态fMRI技术,理解静息状态下,OSAS患者脑结构及功能异常与否,为探索OSAS患者的脑结构和功能提供有价值的依据。

Obstructive sleep apnea syndrome （OSAS） is a common sleep disorder. The patients with OSAS had repeated apnea or hypopnea during sleep, which causes nocturnal asphyxia and wakefulness, so repeated hypoxemia, hypereapnia, and snippet of sleep structures resulted in daytime sleepiness that can affect the disease in all organs of the body. In recent years, functional magnetic resonance imaging （fMRI） provided a new method for the study of the pathogenesis of OSAS. Based on the resting-state fMRI （rs-fMRI） technology, the brain structure and functional abnormality of patients with OSAS was understood, and valuable basis for exploring the brain structure and function of patients with OSAS was provided.