蓝狐“大肾病”的发病机制和防治措施

Mechanism and Prevention of Kidney Enlargement in Arctic Fox

"大肾病"是蓝狐养殖生产中一种常见疾病。它会导致蓝狐幼崽食欲减退、生长迟滞甚至死亡。文中综述了根据流行病学调查和饲养实践结果分析蓝狐"大肾病"发病的可能机制,为遗传上敏感动物(母狐)接触饲料中某些物质后造成肠道免疫异常产生抗食物成分抗体,使胚胎期或出生后幼崽产生被动免疫,进而造成开食断奶后的幼崽连续接触该类抗原后在体内产生抗原抗体复合物,沉积到肾脏造成肾脏损伤和缓慢增生造成肾肿大。通过对该病的发生机制的探讨,提出初步防治措施。

Based on the results of epidemiological investigation and feeding practice, it is argued that mechanism of kidney enlargement in Arctic fox is that some dietary substances cause abnormal intestinal mucosal immune in sensitive female fox, resulting in production of antibody against dietary antigen. The fetus or pups were passively immunized being at supper sensitive stage. The pups are continuously exposed to these dietary substances after they start to eat, thus forming antigen and an- tibody complex depositing in kidney. The deposition of the complex could cause damage to the kidney and enlargement of the organ. Measures for the prevention of the disease were also addressed.