维生素E对2型糖尿病视网膜病变患者血清丙二醛水平的影响

Effect of vitamin E on serum malondialdehyde level in type 2 diabetes mellitus patients with retinopathy

目的探讨维生素E对2型糖尿病视网膜病变患者血清丙二醛水平的影响。方法选取2016年6月至2017年6月解放军第三医院收治的266例2型糖尿病视网膜病变患者为研究对象。给予所有患者维生素E 100 mg/d,早餐后顿服,连续服用3个月。通过眼科检查评估患者眼底情况,根据国际临床糖尿病性视网膜病变(DR)严重程度分级标准将患者分为非增殖型轻度DR组(Ⅰ组,69例)、中度DR组(Ⅱ组,61例)、重度DR组(Ⅲ组,47例)和增殖型DR组(Ⅳ组,89例)。比较治疗前后总体、不同DR程度分组、不同性别间血清丙二醛水平。结果治疗前Ⅲ组、Ⅳ组血清丙二醛水平高于Ⅰ组患者[(4.42±0.15)、(4.84±0.17)μmol/L比(3.62±0.11)μmol/L],差异有统计学意义(P<0.05或P<0.01);治疗后Ⅰ、Ⅱ、Ⅲ、Ⅳ组血清丙二醛水平[(3.44±0.13)、(3.71±0.16)、(4.18±0.17)、(4.72±0.14)μmol/L]均低于治疗前,Ⅳ组仍高于Ⅰ组,差异均有统计学意义(均P<0.05)。男性及女性患者治疗前后各自组内丙二醛水平差异均无统计学意义(均P>0.05)。无论男性和女性,治疗后Ⅰ、Ⅱ、Ⅲ、Ⅳ组丙二醛水平均低于治疗前,差异均有统计学意义(均P<0.05)。结论维生素E对血清丙二醛水平有影响,且与2型糖尿病患者的DR严重程度相关。

Objective To investigate the effect of vitamin E on serum malondialdehyde level in type 2 diabetes mellitus patients with diabetic retinopathy（DR）.Methods From June 2016 to June 2017,266 type 2 diabetic patients with DR were enrolled in the Third Hospital of the Chinese People＇s Liberation Army.All patients took vitamin E 100 mg/d after breakfast for 3 months.Fundus condition was examined and the patients were divided into 4 groups according to the international grading standards：non-proliferative mild DR （group Ⅰ,n =69）,moderate DR（group Ⅱ,n=61）,severe DR（group Ⅲ,n=47） and proliferative DR（group Ⅳ,n =89）.Serum malondialdehyde level was analyzed before and after treatment.Results Before treatment,malondialdehyde in group Ⅲ and group Ⅳ was significantly higher than that in group Ⅰ [（4.42 ±0.15）,（4.84 ±0.17） μmoL/L vs （3.62 ± 0.11） μmol/L] （P 〈 0.05 or P 〈 0.01）.After treatment,malondialdehyde in group Ⅰ,Ⅱ,Ⅲ and Ⅳ [（3.44 ±0.13）,（3.71 ±0.16）,（4.18 ±0.17）,（4.72 ±0.14） μmol/L] was significantly lower than that before treatment;malondialdehyde in group Ⅳ was significantly higher than that in group Ⅰ （P 〈 0.05）.There was no significant difference of malondialdehyde level between male and female patients before and after treatment （P 〉 0.05）.Whether in males or females,malondialdehyde in group Ⅰ,Ⅱ,Ⅲ and Ⅳ after treatment was significantly lower than that before treatment （P 〈 0.05）.Conclusion Vitamin E has an effect on serum malondialdehyde level,which is related to the severity of DR in patients with type 2 diabetes.