甲基纤维素/甘油/聚β-环糊精温敏水凝胶复合体系的构建及搭载疏水性药物研究Ⅰ

Preparation of Composite Temperature-sensitive Methyl Cellulose/glycerin/β-cyclodextrin ploymer hydrogels and Study of Delivery of Hydrophobic Drugs

温敏水凝胶因具有最低临界相转变温度(Lower Critical Solution Temperature,LCST)成为水凝胶材料的研究热点,但其固定的LCST特点在医药领域的应用受到了极大限制。为解决这一难题,研究以甲基纤维素、甘油和聚β-环糊精为原料,构建甲基纤维素/甘油/聚β-环糊精温敏水凝胶体系。实验表明改变甘油的体积百分含量和甲基纤维素浓度可以使水凝胶体系LCST从61℃降低至26℃。同时聚β-环糊精还可以协同降低体系LCST。

Temperature-sensitive hydrogel has the lower critical solution temperature（LCST）, and it has been a hot topic in the research of hydrogels. However, the LCST of temperature-sensitive hydrogel is stationary, the application range of temperature-sensitive hydrogel is severely limited in the field of pharmacology. In order to solve the difficult problem, the composite system of temperature-sensitive hydrogel of methyl cellulose/glycerin/β-cyclodextrin ploymer was prepared. The result proved that the change of glycerol volume percentage and methyl cellulose concentration can reduce the LCST from 61 ℃ to 26 ℃. Meanwhile, β-cyclodextrin ploymer can synergistically reduce the LCST of the system.