尿微量白蛋白、β_2微球蛋白、尿转铁蛋白联合检测对妊娠高血压早期肾损伤的研究及作用

The Diagnostic Significance of the Combined Detection of Urine Micro-albumin,β_2-microglobulin Combine And Urinary Transferrin in Pregnancy-induced Hypertension Patients with Early Kidney Injury

目的通过测定妊娠高血压患者尿微量白蛋白、β_2微球蛋白、尿转铁蛋白水平,探讨这三者联合检测对妊娠高血压患者早期肾脏损伤的诊断意义。方法选择妊娠高血压患者50例作为观察组,另选取50例正常健康孕妇作为对照组,分别采用免疫比浊法、乳胶增强免疫比浊法、尿转铁蛋白试剂盒测定尿微量白蛋白、β_2微球蛋白、尿转铁蛋白水平。结果与对照组相比,观察组患者尿微量白蛋白、β_2微球蛋白、尿转铁蛋白水平较高且差异有统计学意义(P<0.05)。结论高水平的尿微量白蛋白、β_2微球蛋白、尿转铁蛋白与妊娠性高血压患者具有较高的相关性,联合检测三个指标对患者早期肾损伤有明显的诊断意义,且具有较高的准确性和可靠性。

Objective To exam the levels of urinary micro- albumin, β2- microglobulin and urinary transferrin in patients with pregnancy-induced hypertension and to investigate the diagnostic significance of levels of these factors in pregnant women with early kidney injury. Methods 50 cases of pregnancy-induced hypertension were selected as the observation group and 50 cases of normal healthy pregnant women were selected as the control group. Urine microalbumin （urinary albumin ）, β2 Microglobulin, urinary transferrin levels were measured by immunoturbidimetry, latex enhanced turbidimetry and urine transferrin kit, respectively. Results Compared with the control group, levels of urinary albumin, β2 microglobulin and urinary transferrin in the observation group were significant higher（ P 〈 0. 05 ）. Conclusion High levels of urinary microalbumin, β2- microglobulin and urinary transferrin have a strong correlation with patients with gestational hypertension. The combined detection of three factors has promising diagnostic significance in patients with early renal injury. The method shows a high accuracy and reliability.