蛋白质组学在肾脏疾病研究中的应用

Application of proteomics in kidney disease research

研究肾脏疾病发病机制和生物标志物,有助于临床上提高诊断和治疗水平。蛋白质组学是研究发病机制及生物标志物的重要手段。本文对蛋白质组学的发展历史、主要技术方法以及蛋白质组学在IgA肾病、糖尿病肾病、膜性肾病、急性肾损伤和肾癌研究中的应用做了详尽的阐述,并对日后蛋白质组学在肾脏疾病研究中的应用做了展望。

Study on the pathogenesis and biomarkers of renal diseases can improve the diagnosis and treatment clinically. Proteomies is an important discipline to study the pathogenesis and biomarkers. In this paper, the authors elaborated the context including the development history of proteomies, the main technical methods, and proteomies application in the study of IgA nephropathy, diabetic nephropathy, menlbranous nephropathy, acute kidney injury, and renal cell carcinoma. A prospect was also made of the application of proteomies in kidney disease research.