慢性肾脏病铁稳态的研究及治疗进展

Research and treatment progress in iron homeostasis of chronic kidney disease

铁是几乎所有生物存活所必须的微量元素。铁在氧气运输中起到重要作用,铁缺乏会导致贫血,影响氧的供给。在慢性肾脏病中会出现铁代谢的紊乱,使调节铁代谢的细胞因子水平发生变化。慢性肾脏病导致的铁代谢紊乱主要为铁元素缺乏,而补充铁剂的治疗,会导致一系列的氧化应激反应,此为目前临床治疗的难点。认识铁元素在慢性肾脏病中的调节机制是实现铁剂精准治疗的重要前提,本文将从慢性肾脏病中的铁稳态失衡入手,从精准治疗的角度进行综述,以期深入分析铁稳态与慢性肾脏病间的联系,为优化铁剂补充方式提供参考,从而达到减少不良反应的目的。

Iron is the essential trace element for almost all organisms. Due to the function of iron in oxygen transportation, lack of iron may lead to anenfia and affect oxygen supply. Iron metabolisnl disorders may appear in chronic kidney disease （ CKD ） , and make change the levels of cytokines responsible for regulation of iron metabolisnl. Because various causes can lead to iron deficiency in patients with kidney disease, iron supplement therapy is usually given. However, iron supplement therapy may contribute to a series of oxidative stress responses, which is the difficult point in current clinical treatment. Understanding the iron regulation meehanisnl in CKD is an important prerequisite for the precise treatment of iron supplement. The authors started from the imbalance of iron homeostasis in CKD, and focused on precise treatment of iron supplement, hoping to further analyze the relation of iron homeostasis to CKD, in order to provide a reference for optimizing the iron supplement mode, and achieve the purpose of reducing adverse reactions.