阿司匹林预防脑血管病患者早期急性呼吸窘迫综合征的效果

Clinical study of aspirin on the ARDS in patients with acute cerebrovascular disease of early development

目的探讨阿司匹林对急性脑血管病早期发生急性呼吸窘迫综合征(ARDS)的预防作用。方法选取64例急性脑血管病患者按照随机数字表法分为观察组(n=32)和对照组(n=32)。对照组给予常规治疗,观察组在对照组的基础上规律服用阿司匹林。观察两组患者住院早期(<7 d) ARDS的发生率,以及两组患者住院期间机械通气时间、重症加强护理病房(ICU)住院时间以及医疗费用。结果住院早期(<7 d),观察组ARDS的发生率为9. 38%(3/32),明显少于对照组的31. 25%(10/32),差异有统计学意义(P <0. 05);观察组患者机械通气时间、ICU住院时间以及医疗费用明显小于对照组患者,差异具有统计学意义(P <0. 05)。结论阿司匹林治疗能减少急性脑血管病患者早期ARDS的发生率,并有效降低患者机械通气时间、ICU住院时间以及医疗费用。

Objective To investigate the preventive effect of aspirin on acute respiratory- distress syndrom （ARDS） in patients with acute cerebrovascular disease. Methods A total of 64 patients with acute severe cerebrovas- cular disease complicated by ARDS were selected. According to the randomized table method, patients were randomly di- vided into observation group（ n = 32） and control group （n = 32）. The control group received routine treatment,and the observation group regularly took aspirin on the basis of the control group. The incidence of early-stage （ 〈 7 d） ARDS in the two groups was observed, as well as the duration of mechanical ventilation during hospitalization, the length of hospi- tal stay in the Intensive Care Unit （ICU） , and medical expenses. Results In the early stage of hospitalization （ 〈 7 d） , the incidence of ARDS in the observation group was 9.38 % （3/32） ,which was significantly lower than that in the control group[ 31.25% （10/32） ]. The difference was statistically significant （ P 〈 0.05 ）. Ventilation time, ICU hospi- talization time and medical expenses were significantly lower than those of control group, the difference was statistically significant, P 〈 0.05. Conclusion Aspirin treatment can reduce the incidence of early ARDS in patients with acute ce- rebrovascular disease,and reduce effectively the mechanical ventilation time, ICU hospitalization time and medical ex- penses.