人免疫球蛋白联合磷酸肌酸对病毒性心肌炎患儿心肌酶谱的影响

Efficacy of Human Immunoglobulin Combined with Phosphagen on Myocardial Enzyme in Children with Viral Myocarditis

目的观察人免疫球蛋白联合磷酸肌酸对病毒性心肌炎患儿心肌酶谱的影响。方法选择2016年6月~2017年4月我院收治的病毒性心肌炎患儿90例,随机分为对照组和研究组,各45例。对照组进行常规治疗,研究组在常规治疗基础上加用人免疫球蛋白与磷酸肌酸联合治疗,观察两组治疗效果。结果治疗后,对照组NGF、MIP-1α、ICAM-1水平均高于研究组,差异有统计学意义(P<0.05);对照组心肌酶谱指标水平高于研究组,差异有统计学意义(P<0.05);两组治疗期间未发生不良反应。结论在病毒性心肌炎患儿中应用人免疫球蛋白与磷酸肌酸联合治疗疗效显著,可有效改善患儿心肌酶谱水平,利于调节NGF、MIP-1α、ICAM-1水平,且安全性高。

Objective： To observe the efficacy of human immunoglobulin（HIG） combined with phosphagen on myocardial enzyme in children with viral myocarditis.Methods： Totally, 90 children with viral myocarditis were admitted and treated in our hospital from June 2016 to April 2017. They were randomly divided into control group and test group with 45 patients in each group. All patients were given routine treatment, while patients in test group were given human immunoglobulin（HIG） combined with phosphagen additionally. The treatment results was compared between the two groups. Results： After treatment, the levels of NGF, MIP-1α, and ICAM-1 in control group were significantly higher than those in test group. The level of myocardial enzyme in control group was higher than that in test group（P〈0.05）.Conclusions： Human immunoglobulin combined with phosphagen efficacy is significant on improving myocardial enzyme, regulating NGF, MIP-1α, ICAM-1 levels, and has higher safety for treating children with viral myocarditis.