循证医学指导我国肝病临床研究和实践

Evidence-based medicine guides clinical research and practice of liver diseases in China

循证医学已经应用于我国肝病领域指导临床和研究。本期报道了从临床问题出发,用循证医学理念和临床流行病的方法进行科学的顶层设计,开展肝病的诊断、治疗、预后、病因研究和制定临床指南的案例和体会。只有高质量的临床研究才能产生高质量的循证医学证据,成为对患者进行诊治的依据。临床实践指南是临床医师最常用的循证医学证据,指南制定的规范化才能保证指南质量。在应用指南时要让医师和患者充分了解指南的推荐意见并结合患者意愿和实际情况加以实施,增加依从性。将最佳的临床证据结合临床专业知识和经验及患者意愿作出临床诊治决策是循证医学的精髓。

Evidence-based medicine （ EBM ） has been applied in the field of hepatology for guiding the clinicalpractice and research. Experiences and samples of clinical research starting from clinical problems, making top-level design in different directions such as diagnosis,therapy,prognosis and etiology have been reported in this issue. Onlyhigh quality clinical research could become the high quality evidence for making clinical decision. Clinical practice guidelines are the best evidences that doctors commonly use in clinical practice. Standardization of guidelines could ensure its quality. When application of guideline, doctors and patients have to understand its recommendation andcombine with patients ’ concerns for its implementation to increase compliance. It is the core of EBM that best researchevidence combines witli clinical expertise and patients concerns for clinical decision making.