不同HAART治疗方案对中老年患者骨密度的影响

Effects of different HAART treatment regimens on bone mineral density of middle-aged and elderly patients

目的探讨不同高效联合抗反转录病毒治疗(HAART)治疗方案对中老年人骨密度的影响,从而为临床用药提供参考。方法抽取2006—2016年使用抗病毒药物治疗的中老年病人87例,根据不同治疗方案分为五组,其中方案一AZT/3TC+EFV共15例,方案二AZT/3TC+LPV/r的共7例,方案三AZT/3TC+NVP的17例,方案四TDF/3TC+EFV共40例,方案五TDF+3TC+LPV/r的共8例。结果 5种不同HAART方案对中老年人骨密度有不同程度的影响,尤其是TDF/3TC+EFV方案,使用的病人多,对病人的骨密度影响较大。结论医生应定时评估艾滋病患者治疗方案的疗效并定时监测患者骨密度的情况,使患者骨质疏松的发生率减少。

Objective To explore the effects of different highly active anti-retroviral therapy（HAART）regimens on bone mineral density of middle-aged and elderly people,so as to provide references for clinical medication. Methods 87 cases of middle-aged and elderly people who were treated with antiviral drugs from2006 to 2016 were selected and divided into five groups according to different treatment regimens：15 cases in AZT/3 TC＋EFV group（regimen one）,7 cases in AZT/3 TC＋LPV/r group（regimen two）,17 cases in AZT/3 TC＋NVP group（regimen three）,40 cases in TDF/3 TC＋EFV group（regimen four）,8 cases in TDF＋3 TC＋LPV/r group（regimen five）. Results Five different HAART schemes had different effects on bone mineral density of the middle-aged and elderly people,especially the TDF/3 TC＋EFV scheme was used for more patients,and the scheme had a greater influence on the bone mineral density of the patients. Conclusion Doctors should assess the curative efficacy of treatment programs for AIDS patients regularly and monitor the bone density of patients regularly to reduce the incidence of osteoporosis.