卡前列素氨丁三醇与缩宫素联合预防瘢痕子宫孕妇剖宫产术后出血的临床效果

Clinical Effect of Cardoprost Combined with Tromethamine and Oxytocin in Prevention of Postpartum Hemorrhage in Pregnant Women with Scared Uterus

目的探讨卡前列素氨丁三醇与缩宫素联合预防瘢痕子宫孕妇剖宫产术后出血的临床效果。方法随机选取2017年1—12月期间该院收治的150例瘢痕子宫剖宫产孕妇作为研究对象。采取随机数字表法,将150例瘢痕子宫剖宫产孕妇分为实验组、对照组,各75例。对照组单一应用缩宫素预防产后出血,实验组联合应用卡前列素氨丁三醇、缩宫素预防产后出血。比较2组的产后出血发生率、产后24 h出血量及各种不良反应发生率。结果实验组的产后出血发生率9.33%(7/75)明显低于对照组的产后出血发生率25.33%(19/75),差异有统计学意义(χ2=8.541,P=0.013);实验组的产后24 h出血量(201.23±52.37)mL明显低于对照组的产后24 h出血量(335.24±67.81)mL,差异有统计学意义(t=6.528,P=0.037);实验组的不良反应发生率5.33%(4/75),恶心2例,发热1例,腹泻1例,明显低于对照组的不良反应发生率17.33%(13/75),恶心5例,发热3例,腹泻5例,差异有统计学意义(χ2=5.974,P=0.042)。结论卡前列素氨丁三醇与缩宫素联合应用,有利于预防瘢痕子宫孕妇剖宫产术后出血的发生,也可以减少不良反应,值得推广。

Objective To investigate the clinical effect of cardoprost combined with tromethamine and oxytocin in the prevention of postpartum haemorrhage in women with scared uterus. Methods 150 women with uterine cesarean section in the hospital from January to December 2017 were randomly selected as the study subjects. Using a random number table method, 150 cases of cesarean section pregnant women were divided into experimental group and control group, each with75 cases. In the control group, oxytocin was used alone to prevent postpartum hemorrhage. In the experimental group, cardoprost tromethamine and oxytocin were combined to prevent postpartum hemorrhage. The incidence of postpartum hemorrhage, postpartum hemorrhage 24 h, and the incidence of adverse reactions were compared between the two groups. Results The incidence of postpartum hemorrhage in the experimental group was 9.33%（7/75）, which was significantly lower than that in the control group（25.33%, 19/75）. The difference was statistically significant（χ^2=8.541, P=0.013）; The postpartum24 h blood loss（201.23±52.37）mL in the group was significantly lower than that in the control group（post-partum 24 h bleeding（335.24±67.81）mL, and the difference was statistically significant（t=6.528, P=0.037）; The incidence of adverse reactions in the experimental group 5.33%（4/75）, nausea 2 cases, fever 1 case, diarrhea 1 case was significantly lower than the incidence of adverse reactions in the control group 17.33%（13/75） nausea in 5 cases, Fever in 3 cases, diarrhea in 5 cases, the difference was statistically significant（χ^2=5.974, P =0.042）. Conclusion The combination of cardoprost tromethamine and oxytocin can prevent the occurrence of bleeding after cesarean section in pregnant women with scars. It can also reduce adverse reactions and is worthy of promotion.