乙型肝炎病毒感染与肝外肿瘤的相关性研究

The reseach on the relationship between hepatitis B virus infection and extrahepatic tumor

目的了解肝外肿瘤患者乙型肝炎病毒(HBV)感染情况及病毒学指标,探讨HBV感染与肝外肿瘤的相关性。方法收集2016年1月至2017年6月期间该医院肝外肿瘤住院患者500例为病例组;随机选取同期非肿瘤住院患者500例为对照组。采用回顾性方法进行病例对照研究,分析病例组和对照组间乙型肝炎表面抗原(HBsAg)、乙型肝炎表面抗体(抗-HBs)、乙型肝炎核心抗体(抗-HBc)阳性率的差异性。结果胰腺癌和淋巴癌HbsAg阳性率差异有统计学意义(OR=2.231,95%CI:1.149~4.332,P=0.015;OR=3.009,95%CI:1.622~5.580,P=0.000),而乳腺癌、甲状腺癌、肾癌HbsAg阳性率差异均无统计学意义(P>0.05)。甲状腺癌和淋巴癌抗-HBs阳性率差异有统计学意义(OR=0.626,95%CI:0.395~0.990,P=0.044;OR=0.541,95%CI:0.338~0.867,P=0.010),而乳腺癌、肾癌和胰腺癌HbsAg阳性率差异无统计学意义(P>0.05)。肝外肿瘤组与对照组抗-HBc阳性率差异有统计学意义(OR=1.841,95%CI:1.245~2.721,P=0.020),其中乳腺癌、甲状腺癌、肾癌、胰腺癌、淋巴癌与对照组抗-HBc阳性率差异均有统计学意义(P<0.05)。结论 HBV感染与肝外肿瘤的发生存在一定相关性。

Objective To investigate the infection status and virological index of hepatitis B virus （HBV） in patients with extrahepatic tumor,and to discuss the correlation between HBV infection and extrahepatic tumor. Methods 500 extrahepatic tumor patients were collected from January 2016 to June 2017 in hospital as case group.500 non-cancer patients were randomly included in the same period as the control group.HbsAg,anti-HBs and anti-HBc in case group and control group were retrospectly analyzed. Results The positive rate of HbsAg in pancreatic cancer and lymphoma were significantly higher than control group （ OR =2.231,95% CI ：1.149-4.332, P =0.015; OR =3.009,95% CI ：1.622-5.580, P =0.000）.However,there were no significant difference in thyroid cancer and renal cell carcinoma （ P 〉0.05）.The positive rate of anti-HBs in thyroid carcinoma and lymphoma were significantly higher than control group （ OR =0.626,95% CI ：0.395-0.990, P = 0.044 ; OR =0.626,95% CI ：0.338-0.867, P =0.010）,but there were no significant difference in breast cancer,kidney cancer and pancreatic cancer （ P 〉0.05）.There was significant difference between extrahepatic tumor and control group （ OR =1.841,95% CI ：1.245-2.721, P =0.020）.Among extrahepatic tumor,the breast cancer,thyroid cancer,kidney cancer,pancreatic cancer and lymphoma were significantly higher than control group （ P 〈0.05）. Conclusion HBV infection was closely related to extrahepatic tumor.